publication . Article . Other literature type . 2012

Genetics of rheumatoid arthritis

Ruyssen-Witrand, Adeline; Constantin, Arnaud; Cambon-Thomsen, Anne; Thomsen, Mogens;
Open Access English
  • Published: 01 Aug 2012
  • Publisher: HAL CCSD
  • Country: France
Abstract
International audience; Rheumatoid arthritis (RA) is a common autoimmune disease with a strong genetic component. Numerous aberrant immune responses have been described during the evolution of the disease. In later years, the appearance of anti-citrullinated protein antibodies (ACPAs) has become a hallmark for the diagnosis and prognosis of RA. The post-translational transformation of arginine residues of proteins and peptides into citrulline (citrullination) is a natural process in the body, but for unknown reasons autoreactivity towards citrullinated residues may develop in disposed individuals. ACPAs are often found years before clinical manifestations. ACPAs...
Subjects
Medical Subject Headings: musculoskeletal diseasesskin and connective tissue diseasesimmune system diseases
free text keywords: Rheumatoid arthritis, single nucleotide polymorphisms, genetics, immune response, autoantibodies, citrullination, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Immunology, Immunology and Allergy, Biochemistry, General Medicine, Autoimmune disease, medicine.disease, medicine, Biology, Human leukocyte antigen, Disease, Autoantibody, Immune system, Single-nucleotide polymorphism, Antibody, biology.protein
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publication . Article . Other literature type . 2012

Genetics of rheumatoid arthritis

Ruyssen-Witrand, Adeline; Constantin, Arnaud; Cambon-Thomsen, Anne; Thomsen, Mogens;