publication . Other literature type . Article . 2014

Gender and incidence of dementia in the Framingham Heart Study from mid-adult life

Chêne, Geneviève; Beiser, Alexa; Au, Rhoda; Preis, Sarah R; Wolf, Philip A; Dufouil, Carole; Seshadri, Sudha;
  • Published: 10 Jan 2014
  • Publisher: Wiley
  • Country: France
International audience; BACKGROUND: Gender-specific risks for dementia and Alzheimer's disease (AD) starting in midlife remain largely unknown. METHODS: Prospectively ascertained dementia/AD and cause-specific mortality in Framingham Heart Study (FHS) participants was used to generate 10- to 50-year risk estimates of dementia/AD on the basis of the Kaplan-Meier method (cumulative incidence) or accounting for competing risk of death (lifetime risk [LTR]). RESULTS: Overall, 777 cases of incident dementia (601 AD) occurred in 7901 participants (4333 women) over 136,266 person-years. Whereas cumulative incidences were similar in women and men, LTRs were higher in wo...
free text keywords: incidence of dementia, Alzheimer's disease, gender, mortality, cardiovascular risk profile, selective survival, cohort/population-based cohort, prevention, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Article, Health Policy, Developmental Neuroscience, Epidemiology, Cellular and Molecular Neuroscience, Geriatrics and Gerontology, Psychiatry and Mental health, Clinical Neurology, Gerontology, Diabetes mellitus, medicine.disease, medicine, Risk assessment, Survival analysis, Dementia, Prospective cohort study, business.industry, business, Disease, Cumulative incidence, Framingham Heart Study
Funded by
  • Funder: National Institutes of Health (NIH)
  • Project Code: N01HC025195-005
NIH| ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2U01HL096917-05
48 references, page 1 of 4

[1] Kivipelto M, Ngandu T, Laatikainen T, Winblad B, Soininen H, Tuomilehto J. Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study. Lancet Neurol 2006;5:735-41. [OpenAIRE]

[2] Buchman AS, Boyle PA, Yu L, Shah RC, Wilson RS, Bennett DA. Total daily physical activity and the risk of AD and cognitive decline in older adults. Neurology 2012;78:1323-9.

[3] Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. NatGenet 2009;41:1094-9.

[4] Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 2010;303:1832-40.

[5] Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 2011;43:429-35.

[6] Brayne C, Best N, Muir M, Richards SJ, Gill C. Five-year incidence and prediction of dementia and cognitive decline in a population sample of women aged 70-79 at baseline. Int J Geriatr Psychiatry 1997;12:1107-18.

[7] Yoshitake Y, Kiyohara Y, Kato I, Ohmura T, Iwamoto H, Nakayama K, et al. Incidence and risk factors of vascular dementia and alzheimer's disease in a defined elderly Japanese population: The Hisayama study. Neurology 1995;45:1161-8.

[8] Kukull WA, Higdon R, Bowen JD, McCormick WC, Teri L, Schellenberg GD, et al. Dementia and Alzheimer disease incidence: a prospective cohort study. ArchNeurol 2002;59:1737-46. [OpenAIRE]

[9] Barnes LL, Wilson RS, Schneider JA, Bienias JL, Evans DA, Bennett DA. Gender, cognitive decline, and risk of AD in older persons. Neurology 2003;60:1777-81. [OpenAIRE]

[10] Hebert LE, Scherr PA, McCann JJ, Beckett LA, Evans DA. Is the risk of developing Alzheimer's disease greater for women than for men? AmJEpidemiol 2001;153:132-6. [OpenAIRE]

[11] Miech RA, Breitner JCS, Zandi PP, Khachaturian AS, Anthony JC, Mayer L. Incidence of AD may decline in the early 90s for men, later for women - The Cache County study. Neurology 2002;58:209-18. [OpenAIRE]

[12] Paykel ES, Brayne C, Huppert FA, Gill C, Barkley C, Gehlhaar E, et al. Incidence of dementia in a population older than 75 years in the United Kingdom. Arch Gen Psychiatry 1994;51:325-32. [OpenAIRE]

[13] Bachman DL, Wolf PA, Linn RT, Knoefel JE, Cobb JL, Belanger AJ, et al. Incidence of dementia and probable Alzheimer's disease in a general population: the Framingham Study. Neurology 1993;43:515-9. [OpenAIRE]

[14] Rocca WA, Cha RH, Waring SC, Kokmen E. Incidence of dementia and Alzheimer's disease: A reanalysis of data from Rochester, Minnesota, 1975-1984. AmJEpidemiol 1998;148:51-62. [OpenAIRE]

[15] Andersen K, Launer LJ, Dewey ME, Letenneur L, Ott A, Copeland JR, et al. Gender differences in the incidence of AD and vascular dementia - The EURODEM Studies. Neurology 1999;53:1992-7. [OpenAIRE]

48 references, page 1 of 4
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Other literature type . Article . 2014

Gender and incidence of dementia in the Framingham Heart Study from mid-adult life

Chêne, Geneviève; Beiser, Alexa; Au, Rhoda; Preis, Sarah R; Wolf, Philip A; Dufouil, Carole; Seshadri, Sudha;