publication . Other literature type . Article . 2014

Gender and incidence of dementia in the Framingham Heart Study from mid-adult life

Chêne, Geneviève; Beiser, Alexa; Au, Rhoda; Preis, Sarah R; Wolf, Philip A; Dufouil, Carole; Seshadri, Sudha;
  • Published: 10 Jan 2014
  • Publisher: Wiley
  • Country: France
Abstract
International audience; BACKGROUND: Gender-specific risks for dementia and Alzheimer's disease (AD) starting in midlife remain largely unknown. METHODS: Prospectively ascertained dementia/AD and cause-specific mortality in Framingham Heart Study (FHS) participants was used to generate 10- to 50-year risk estimates of dementia/AD on the basis of the Kaplan-Meier method (cumulative incidence) or accounting for competing risk of death (lifetime risk [LTR]). RESULTS: Overall, 777 cases of incident dementia (601 AD) occurred in 7901 participants (4333 women) over 136,266 person-years. Whereas cumulative incidences were similar in women and men, LTRs were higher in wo...
Subjects
free text keywords: incidence of dementia, Alzheimer's disease, gender, mortality, cardiovascular risk profile, selective survival, cohort/population-based cohort, prevention, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Article, Health Policy, Developmental Neuroscience, Epidemiology, Cellular and Molecular Neuroscience, Geriatrics and Gerontology, Psychiatry and Mental health, Clinical Neurology, Gerontology, Diabetes mellitus, medicine.disease, medicine, Risk assessment, Survival analysis, Dementia, Prospective cohort study, business.industry, business, Disease, Cumulative incidence, Framingham Heart Study
Funded by
NIH| THE FRAMINGHAM HEART STUDY-268025195
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: N01HC025195-005
  • Funding stream: DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS
,
NIH| ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2U01HL096917-05
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
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publication . Other literature type . Article . 2014

Gender and incidence of dementia in the Framingham Heart Study from mid-adult life

Chêne, Geneviève; Beiser, Alexa; Au, Rhoda; Preis, Sarah R; Wolf, Philip A; Dufouil, Carole; Seshadri, Sudha;