publication . Article . 2014

Does consumption of LC omega-3 PUFA enhance cognitive performance in healthy school-aged children and throughout adulthood? Evidence from clinical trials.

Stonehouse Welma;
Open Access English
  • Published: 01 Jul 2014 Journal: Nutrients, volume 6, issue 7, pages 2,730-2,758 (eissn: 2072-6643, Copyright policy)
  • Publisher: MDPI
Abstract
Long-chain (LC) omega-3 PUFA derived from marine sources may play an important role in cognitive performance throughout all life stages. Docosahexaenoic acid (DHA), the dominant omega-3 in the brain, is a major component of neuronal cell membranes and affects various neurological pathways and processess. Despite its critical role in brain function, human’s capacity to synthesize DHA de novo is limited and its consumption through the diet is important. However, many individuals do not or rarely consume seafood. The aim of this review is to critically evaluate the current evidence from randomised controlled trials (RCT) in healthy school-aged children, younger and...
Subjects
Medical Subject Headings: food and beverages
free text keywords: Review, long-chain omega-3 polyunsaturated fatty acids, docosahexaenoic acid, DHA, cognitive performance, healthy, children, adults, older adults, Nutrition. Foods and food supply, TX341-641, Food Science, Internal medicine, medicine.medical_specialty, medicine, Evidence-based practice, Elementary cognitive task, Gerontology, business.industry, business, Cognitive decline, Young adult, Endocrinology, Effects of sleep deprivation on cognitive performance, Cognition, Randomized controlled trial, law.invention, law, Cognitive development
90 references, page 1 of 6

Arterburn, L.M., Hall, E.B., Oken, H.. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am. J. Clin. Nutr.. 2006; 83: 1467S-1476S [OpenAIRE] [PubMed]

Chung, W.L., Chen, J.J., Su, H.M.. Fish oil supplementation of control and (n-3) fatty acid-deficient male rats enhances reference and working memory performance and increases brain regional docosahexaenoic acid levels. J. Nutr.. 2008; 138: 1165-1171 [PubMed]

Gamoh, S., Hashimoto, M., Sugioka, K., Hossain, M.S., Hata, N., Misawa, Y., Masumura, S.. Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats. Neuroscience. 1999; 93: 237-241 [OpenAIRE] [PubMed] [DOI]

Horrocks, L.A., Farooqui, A.A.. Docosahexaenoic acid in the diet: Its importance in maintenance and restoration of neural membrane function. Prostaglandins Leukotrienes Essent. Fatty Acids. 2004; 70: 361-372 [OpenAIRE] [DOI]

Innis, S.M.. Dietary (n-3) fatty acids and brain development. J. Nutr.. 2007; 137: 855-859 [PubMed]

Luchtman, D.W., Song, C.. Cognitive enhancement by omega-3 fatty acids from child-hood to old age: Findings from animal and clinical studies. Neuropharmacology. 2013; 64: 550-565 [OpenAIRE] [PubMed] [DOI]

Parletta, N., Milte, C.M., Meyer, B.J.. Nutritional modulation of cognitive function and mental health. J. Nutr. Biochem.. 2013; 24: 725-743 [OpenAIRE] [PubMed] [DOI]

Tassoni, D., Kaur, G., Weisinger, R.S., Sinclair, A.J.. The role of eicosanoids in the brain. Asia Pac. J. Clin. Nutr.. 2008; 17: 220-228 [PubMed]

Jackson, P.A., Reay, J.L., Scholey, A.B., Kennedy, D.O.. DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: A near IR spectroscopy pilot study. Br. J. Nutr.. 2012; 107: 1093-1098 [OpenAIRE] [PubMed] [DOI]

Cunnane, S.C., Plourde, M., Pifferi, F., Begin, M., Feart, C., Barberger-Gateau, P.. Fish, docosahexaenoic acid and Alzheimer’s disease. Progr. Lipid Res.. 2009; 48: 239-256 [OpenAIRE] [DOI]

Rapoport, S.I.. Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo. Prostaglandins Leukotrienes Essent. Fatty Acids. 2013; 88: 79-85 [OpenAIRE] [DOI]

Freemantle, E., Vandal, M., Tremblay-Mercier, J., Tremblay, S., Blachere, J.C., Begin, M.E., Brenna, J.T., Windust, A., Cunnane, S.C.. Omega-3 fatty acids, energy substrates, and brain function during aging. Prostaglandins Leukotrienes Essent. Fatty Acids. 2006; 75: 213-220 [OpenAIRE] [DOI]

Umhau, J.C., Zhou, W., Carson, R.E., Rapoport, S.I., Polozova, A., Demar, J., Hussein, N., Bhattacharjee, A.K., Ma, K., Esposito, G.. Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography. J. Lipid Res.. 2009; 50: 1259-1268 [OpenAIRE] [PubMed] [DOI]

Moriguchi, T., Salem, N.. Recovery of brain docosahexaenoate leads to recovery of spatial task performance. J. Neurochem.. 2003; 87: 297-309 [OpenAIRE] [PubMed] [DOI]

Barcelo-Coblijn, G., Murphy, E.J.. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: Benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Progr. Lipid Res.. 2009; 48: 355-374 [OpenAIRE] [DOI]

90 references, page 1 of 6
Abstract
Long-chain (LC) omega-3 PUFA derived from marine sources may play an important role in cognitive performance throughout all life stages. Docosahexaenoic acid (DHA), the dominant omega-3 in the brain, is a major component of neuronal cell membranes and affects various neurological pathways and processess. Despite its critical role in brain function, human’s capacity to synthesize DHA de novo is limited and its consumption through the diet is important. However, many individuals do not or rarely consume seafood. The aim of this review is to critically evaluate the current evidence from randomised controlled trials (RCT) in healthy school-aged children, younger and...
Subjects
Medical Subject Headings: food and beverages
free text keywords: Review, long-chain omega-3 polyunsaturated fatty acids, docosahexaenoic acid, DHA, cognitive performance, healthy, children, adults, older adults, Nutrition. Foods and food supply, TX341-641, Food Science, Internal medicine, medicine.medical_specialty, medicine, Evidence-based practice, Elementary cognitive task, Gerontology, business.industry, business, Cognitive decline, Young adult, Endocrinology, Effects of sleep deprivation on cognitive performance, Cognition, Randomized controlled trial, law.invention, law, Cognitive development
90 references, page 1 of 6

Arterburn, L.M., Hall, E.B., Oken, H.. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am. J. Clin. Nutr.. 2006; 83: 1467S-1476S [OpenAIRE] [PubMed]

Chung, W.L., Chen, J.J., Su, H.M.. Fish oil supplementation of control and (n-3) fatty acid-deficient male rats enhances reference and working memory performance and increases brain regional docosahexaenoic acid levels. J. Nutr.. 2008; 138: 1165-1171 [PubMed]

Gamoh, S., Hashimoto, M., Sugioka, K., Hossain, M.S., Hata, N., Misawa, Y., Masumura, S.. Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats. Neuroscience. 1999; 93: 237-241 [OpenAIRE] [PubMed] [DOI]

Horrocks, L.A., Farooqui, A.A.. Docosahexaenoic acid in the diet: Its importance in maintenance and restoration of neural membrane function. Prostaglandins Leukotrienes Essent. Fatty Acids. 2004; 70: 361-372 [OpenAIRE] [DOI]

Innis, S.M.. Dietary (n-3) fatty acids and brain development. J. Nutr.. 2007; 137: 855-859 [PubMed]

Luchtman, D.W., Song, C.. Cognitive enhancement by omega-3 fatty acids from child-hood to old age: Findings from animal and clinical studies. Neuropharmacology. 2013; 64: 550-565 [OpenAIRE] [PubMed] [DOI]

Parletta, N., Milte, C.M., Meyer, B.J.. Nutritional modulation of cognitive function and mental health. J. Nutr. Biochem.. 2013; 24: 725-743 [OpenAIRE] [PubMed] [DOI]

Tassoni, D., Kaur, G., Weisinger, R.S., Sinclair, A.J.. The role of eicosanoids in the brain. Asia Pac. J. Clin. Nutr.. 2008; 17: 220-228 [PubMed]

Jackson, P.A., Reay, J.L., Scholey, A.B., Kennedy, D.O.. DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: A near IR spectroscopy pilot study. Br. J. Nutr.. 2012; 107: 1093-1098 [OpenAIRE] [PubMed] [DOI]

Cunnane, S.C., Plourde, M., Pifferi, F., Begin, M., Feart, C., Barberger-Gateau, P.. Fish, docosahexaenoic acid and Alzheimer’s disease. Progr. Lipid Res.. 2009; 48: 239-256 [OpenAIRE] [DOI]

Rapoport, S.I.. Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo. Prostaglandins Leukotrienes Essent. Fatty Acids. 2013; 88: 79-85 [OpenAIRE] [DOI]

Freemantle, E., Vandal, M., Tremblay-Mercier, J., Tremblay, S., Blachere, J.C., Begin, M.E., Brenna, J.T., Windust, A., Cunnane, S.C.. Omega-3 fatty acids, energy substrates, and brain function during aging. Prostaglandins Leukotrienes Essent. Fatty Acids. 2006; 75: 213-220 [OpenAIRE] [DOI]

Umhau, J.C., Zhou, W., Carson, R.E., Rapoport, S.I., Polozova, A., Demar, J., Hussein, N., Bhattacharjee, A.K., Ma, K., Esposito, G.. Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography. J. Lipid Res.. 2009; 50: 1259-1268 [OpenAIRE] [PubMed] [DOI]

Moriguchi, T., Salem, N.. Recovery of brain docosahexaenoate leads to recovery of spatial task performance. J. Neurochem.. 2003; 87: 297-309 [OpenAIRE] [PubMed] [DOI]

Barcelo-Coblijn, G., Murphy, E.J.. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: Benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Progr. Lipid Res.. 2009; 48: 355-374 [OpenAIRE] [DOI]

90 references, page 1 of 6
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