publication . Article . 2004

Connexin 32 gap junctions enhance stimulation of glucose output by glucagon and noradrenaline in mouse liver

Frank Stümpel; Thomas Ott; Kurt Jungermann; Klaus Willecke;
Restricted
  • Published: 28 Jul 2004 Journal: Hepatology, volume 28, pages 1,616-1,620 (issn: 0270-9139, Copyright policy)
  • Publisher: Wiley
Abstract
Gap junctions connect neighboring cells via intercellular channels composed of connexins (Cx). Connexin 32 (Cx32) is the main connexin in hepatocytes. Gap junctions propagate a signal from periportal to perivenous hepatocytes generated by electrical stimulation of sympathetic liver nerves. Therefore, it was the aim of this study to examine the involvement of hepatocellular gap junctions in hormonal regulation. In perfused livers from wild-type mice and Cx32-deficient mice, the stimulation of glucose release by varying noradrenaline and glucagon concentrations was investigated. At saturating hormone concentrations, glucose release was the same in wild-type and Cx...
Persistent Identifiers
Subjects
free text keywords: Connexin 32, education.field_of_study, education, Hepatocyte, medicine.anatomical_structure, medicine, Biology, Glucagon, Connexin, Carbohydrate metabolism, Stimulation, Endocrinology, medicine.medical_specialty, Internal medicine, Tight junction, Gap junction
Related Organizations
Related research
Abstract
Gap junctions connect neighboring cells via intercellular channels composed of connexins (Cx). Connexin 32 (Cx32) is the main connexin in hepatocytes. Gap junctions propagate a signal from periportal to perivenous hepatocytes generated by electrical stimulation of sympathetic liver nerves. Therefore, it was the aim of this study to examine the involvement of hepatocellular gap junctions in hormonal regulation. In perfused livers from wild-type mice and Cx32-deficient mice, the stimulation of glucose release by varying noradrenaline and glucagon concentrations was investigated. At saturating hormone concentrations, glucose release was the same in wild-type and Cx...
Persistent Identifiers
Subjects
free text keywords: Connexin 32, education.field_of_study, education, Hepatocyte, medicine.anatomical_structure, medicine, Biology, Glucagon, Connexin, Carbohydrate metabolism, Stimulation, Endocrinology, medicine.medical_specialty, Internal medicine, Tight junction, Gap junction
Related Organizations
Related research
Any information missing or wrong?Report an Issue