publication . Article . Other literature type . 2018

Updated Meta-Analysis of BIN1 , CR1 , MS4A6A , CLU , and ABCA7 Variants in Alzheimer’s Disease

Jucimara Ferreira Figueiredo Almeida; Flavia de Paula;
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  • Published: 04 Mar 2018 Journal: Journal of Molecular Neuroscience, volume 64, pages 471-477 (issn: 0895-8696, eissn: 1559-1166, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Genome-wide association studies (GWAS) have associated several genetic variants with late-onset Alzheimer’s disease (LOAD), a neurodegenerative disease. Among those, rs3764650 ABCA7, rs6656401 CR1, and rs744373 BIN1 were associated as risk factors for LOAD, while rs11136000 CLU and rs610932 MS4A6A were protective. Recently, several case-control studies have investigated the association of these polymorphisms with AD. However, not all meta-analyses analyzed these variants across different ethnic groups. Therefore, we performed an updated meta-analysis of rs3764650 ABCA7, rs6656401 CR1, rs744373 BIN1, rs11136000 CLU, and rs610932 MS4A6A variants associated with LO...
Subjects
free text keywords: Cellular and Molecular Neuroscience, General Medicine
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