publication . Other literature type . Article . 2001

Merlin--rapid analysis of dense genetic maps using sparse gene flow trees.

Goncalo Abecasis; Stacey Cherny;
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  • Published: 03 Dec 2001
  • Publisher: Springer Science and Business Media LLC
Abstract
Efforts to find disease genes using high-density single-nucleotide polymorphism (SNP) maps will produce data sets that exceed the limitations of current computational tools. Here we describe a new, efficient method for the analysis of dense genetic maps in pedigree data that provides extremely fast solutions to common problems such as allele-sharing analyses and haplotyping. We show that sparse binary trees represent patterns of gene flow in general pedigrees in a parsimonious manner, and derive a family of related algorithms for pedigree traversal. With these trees, exact likelihood calculations can be carried out efficiently for single markers or for multiple ...
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