publication . Article . Other literature type . 1999

Assessment of Linkage Disequilibrium by the Decay of Haplotype Sharing, with Application to Fine-Scale Genetic Mapping

McPeek, M S; Strahs, A;
Open Access
  • Published: 01 Sep 1999 Journal: The American Journal of Human Genetics, volume 65, pages 858-875 (issn: 0002-9297, Copyright policy)
  • Publisher: Elsevier BV
Abstract
SummaryLinkage disequilibrium (LD) is of great interest for gene mapping and the study of population history. We propose a multilocus model for LD, based on the decay of haplotype sharing (DHS). The DHS model is most appropriate when the LD in which one is interested is due to the introduction of a variant on an ancestral haplotype, with recombinations in succeeding generations resulting in preservation of only a small region of the ancestral haplotype around the variant. This is generally the scenario of interest for gene mapping by LD. The DHS parameter is a measure of LD that can be interpreted as the expected genetic distance to which the ancestral haplotype...
Subjects
free text keywords: Genetics(clinical), Genetics, Gene mapping, Quasi-likelihood, Haplotype estimation, Modal haplotype, Haplotype, Linkage disequilibrium, Population, education.field_of_study, education, Locus (genetics), Biology, Quasi likelihood, Coalescence, Disequilibrium measure, Hidden Markov model, Estimating equation, Research Article
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