publication . Other literature type . Article . 2012

Striatal amyloid plaque density predicts Braak neurofibrillary stage and clinicopathological Alzheimer's disease: implications for amyloid imaging.

Thomas G. Beach; Lucia I. Sue; Douglas G. Walker; Marwan N. Sabbagh; Geidy Serrano; Brittany N. Dugger; Monica Mariner; Kim Yantos; Jonette Henry-Watson; Glenn Chiarolanza; ...
  • Published: 20 Feb 2012
  • Publisher: IOS Press
Abstract
Amyloid imaging may revolutionize Alzheimer’s disease (AD) research and clinical practice but is critically limited by an inadequate correlation between cerebral cortex amyloid plaques and dementia. Also, amyloid imaging does not indicate the extent of neurofibrillary tangle (NFT) spread throughout the brain. Currently, the presence of dementia as well as a minimal brain load of both plaques and NFTs is required for the diagnosis of AD. Autopsy studies suggest that striatal amyloid plaques may be mainly restricted to subjects in higher Braak NFT stages that meet clinicopathological diagnostic criteria for AD. Striatal plaques, which are readily identified by amy...
Subjects
Medical Subject Headings: mental disorders
free text keywords: Article, Clinical Psychology, Geriatrics and Gerontology, Psychiatry and Mental health, General Medicine, Dementia, medicine.disease, medicine, Psychology, Neurofibrillary tangle, Pathology, medicine.medical_specialty, Amyloid, Cerebral cortex, medicine.anatomical_structure, Asymptomatic, medicine.symptom, Alzheimer's disease, Disease, Autopsy
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