publication . Article . 2010

Mycolactone Suppresses T Cell Responsiveness by Altering Both Early Signaling and Posttranslational Events

Caroline Demangel;
Open Access English
  • Published: 01 Feb 2010
  • Publisher: HAL CCSD
  • Country: France
Abstract
International audience; Mycolactone is a diffusible lipid toxin produced by Mycobacterium ulcerans, the causative agent of a necrotizing skin disease referred to as Buruli ulcer. Intriguingly, patients with progressive lesions display a systemic suppression of Th1 responses that resolves on surgical excision of infected tissues. In this study, we examined the effects of mycolactone on the functional biology of T cells and identified two mechanisms by which mycolactone suppresses cell responsiveness to antigenic stimulation. At noncytotoxic concentrations, mycolactone blocked the activation-induced production of cytokines by a posttranscriptional, mammalian targe...
Subjects
free text keywords: MESH: Animals, MESH: Bacterial Toxins, MESH: Lymphocyte Specific Protein Tyrosine Kinase p56(lck), MESH: Mice, MESH: Mice, Inbred C57BL, MESH: Mycobacterium ulcerans, MESH: Protein Processing, Post-Translational, MESH: Signal Transduction, MESH: T-Lymphocytes, MESH: Time Factors, MESH: Buruli Ulcer, MESH: Cells, Cultured, MESH: Humans, MESH: Immunity, Cellular, MESH: Immunosuppressive Agents, MESH: Intracellular Fluid, MESH: Jurkat Cells, MESH: Lymphocyte Activation, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, MESH : Animals, MESH : Bacterial Toxins, MESH : Lymphocyte Specific Protein Tyrosine Kinase p56(lck), MESH : Mice, MESH : Mice, Inbred C57BL, MESH : Mycobacterium ulcerans, MESH : Protein Processing, Post-Translational, MESH : Signal Transduction, MESH : T-Lymphocytes, MESH : Time Factors, MESH : Buruli Ulcer, MESH : Cells, Cultured, MESH : Humans, MESH : Immunity, Cellular, MESH : Immunosuppressive Agents, MESH : Intracellular Fluid, MESH : Jurkat Cells, MESH : Lymphocyte Activation, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, Immunology
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