publication . Article . Other literature type . 2002

Losing heart: the role of apoptosis in heart disease—a novel therapeutic target?

Gill, C.; Mestril, R.; Afshin Samali;
Open Access
  • Published: 01 Feb 2002 Journal: The FASEB Journal, volume 16, pages 135-146 (issn: 0892-6638, eissn: 1530-6860, Copyright policy)
  • Publisher: Wiley
Abstract
Cardiovascular disease is a leading cause of death worldwide. In recent years it has emerged that loss of myocardial cells may be a major pathogenic factor. Cell death can occur in a destructive, uncontrolled manner via necrosis or by a highly regulated programmed cell suicide mechanism termed apoptosis. As cell death in conditions such as heart failure and myocardial infarction does not always follow a typically apoptotic pathway, it remains to be established whether it occurs by apoptosis, necrosis, or a novel uncharacterized mechanism combining aspects of both types of cell death. Apoptotic pathways have been well studied in nonmyocytes and it is thought that...
Subjects
free text keywords: Biotechnology, Genetics, Biochemistry, Molecular Biology, Mitochondrion, Cell biology, Necrosis, medicine.symptom, medicine, Apoptosis, Caspase, biology.protein, biology, Cause of death, Cardiomyopathy, medicine.disease, Programmed cell death, Heart disease
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