publication . Article . Other literature type . 2014

Autosis and autophagic cell death: the dark side of autophagy

Liu, Y; Levine, B;
Open Access
  • Published: 26 Sep 2014 Journal: Cell Death & Differentiation, volume 22, pages 367-376 (issn: 1350-9047, eissn: 1476-5403, Copyright policy)
  • Publisher: Springer Nature
Abstract
It is controversial whether cells truly die via autophagy or whether — in dying cells — autophagy is merely an innocent bystander or a well-intentioned ‘Good Samaritan' trying to prevent inevitable cellular demise. However, there is increasing evidence that the genetic machinery of autophagy may be essential for cell death in certain settings. We recently identified a novel form of autophagy gene-dependent cell death, termed autosis, which is mediated by the Na+,K+-ATPase pump and has unique morphological features. High levels of cellular autophagy, as occurs with treatment with autophagy-inducing peptides, starvation, or in vivo during certain types of ischemia...
Subjects
free text keywords: Cell Biology, Molecular Biology, Programmed cell death, Cell growth, Biology, Extreme stress, Autophagy, Apoptosis, Bystander effect, Cellular Autophagy, Neurodegeneration, medicine.disease, medicine, Review
Funded by
NIH| Enhancing ATG-dependent Defense Against Pathogens w/Therapeutics Lead CP
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U19AI109725-03
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| Beclin 1 Bcl-2 Interactions: Effects on Apoptosis
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA109618-03
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Analysis of beclin 1 in autophagy and tumor suppression
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA084254-09
  • Funding stream: NATIONAL CANCER INSTITUTE
96 references, page 1 of 7

Clarke, PG. Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol (Berl). 1990; 181: 195-213 [PubMed]

Schweichel, JU, Merker, HJ. The morphology of various types of cell death in prenatal tissues. Teratology. 1973; 7: 253-266 [OpenAIRE] [PubMed]

Levine, B, Yuan, J. Autophagy in cell death: an innocent convict. J Clin Invest. 2005; 115: 2679-2688 [OpenAIRE] [PubMed]

Galluzzi, L, Vitale, I, Abrams, JM, Alnemri, ES, Baehrecke, EH, Blagosklonny, MV. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2012; 19: 107-120 [OpenAIRE] [PubMed]

Liu, Y, Shoji-Kawata, S, Sumpter, RM, Wei, Y, Ginet, V, Zhang, L. Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Proc Natl Acad Sci USA. 2013; 110: 20364-20371 [OpenAIRE] [PubMed]

Green, DR, Levine, B. To be or not to be? How selective autophagy and cell death govern cell fate. Cell. 2014; 157: 65-75 [OpenAIRE] [PubMed]

He, C, Bassik, MC, Moresi, V, Sun, K, Wei, Y, Zou, Z. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 2012; 481: 511-515 [OpenAIRE] [PubMed]

Choi, AM, Ryter, SW, Levine, B. Autophagy in human health and disease. N Engl J Med. 2013; 368: 651-662 [OpenAIRE] [PubMed]

Simonsen, A, Tooze, SA. Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J Cell Biol. 2009; 186: 773-782 [OpenAIRE] [PubMed]

Ohsumi, Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol. 2001; 2: 211-216 [OpenAIRE] [PubMed]

Kroemer, G, Levine, B. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol. 2008; 9: 1004-1010 [OpenAIRE] [PubMed]

Hofius, D, Schultz-Larsen, T, Joensen, J, Tsitsigiannis, DI, Petersen, NH, Mattsson, O. Autophagic components contribute to hypersensitive cell death in Arabidopsis. Cell. 2009; 137: 773-783 [OpenAIRE] [PubMed]

Hackenberg, T, Juul, T, Auzina, A, Gwizdz, S, Malolepszy, A, Van Der Kelen, K. Catalase and NO CATALASE ACTIVITY1 promote autophagy-dependent cell death in Arabidopsis. Plant Cell. 2013; 25: 4616-4626 [OpenAIRE] [PubMed]

Shimizu, S, Kanaseki, T, Mizushima, N, Mizuta, T, Arakawa-Kobayashi, S, Thompson, CB. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol. 2004; 6: 1221-1228 [OpenAIRE] [PubMed]

Shimizu, S, Konishi, A, Nishida, Y, Mizuta, T, Nishina, H, Yamamoto, A. Involvement of JNK in the regulation of autophagic cell death. Oncogene. 2010; 29: 2070-2082 [PubMed]

96 references, page 1 of 7
Abstract
It is controversial whether cells truly die via autophagy or whether — in dying cells — autophagy is merely an innocent bystander or a well-intentioned ‘Good Samaritan' trying to prevent inevitable cellular demise. However, there is increasing evidence that the genetic machinery of autophagy may be essential for cell death in certain settings. We recently identified a novel form of autophagy gene-dependent cell death, termed autosis, which is mediated by the Na+,K+-ATPase pump and has unique morphological features. High levels of cellular autophagy, as occurs with treatment with autophagy-inducing peptides, starvation, or in vivo during certain types of ischemia...
Subjects
free text keywords: Cell Biology, Molecular Biology, Programmed cell death, Cell growth, Biology, Extreme stress, Autophagy, Apoptosis, Bystander effect, Cellular Autophagy, Neurodegeneration, medicine.disease, medicine, Review
Funded by
NIH| Enhancing ATG-dependent Defense Against Pathogens w/Therapeutics Lead CP
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U19AI109725-03
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| Beclin 1 Bcl-2 Interactions: Effects on Apoptosis
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA109618-03
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Analysis of beclin 1 in autophagy and tumor suppression
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA084254-09
  • Funding stream: NATIONAL CANCER INSTITUTE
96 references, page 1 of 7

Clarke, PG. Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol (Berl). 1990; 181: 195-213 [PubMed]

Schweichel, JU, Merker, HJ. The morphology of various types of cell death in prenatal tissues. Teratology. 1973; 7: 253-266 [OpenAIRE] [PubMed]

Levine, B, Yuan, J. Autophagy in cell death: an innocent convict. J Clin Invest. 2005; 115: 2679-2688 [OpenAIRE] [PubMed]

Galluzzi, L, Vitale, I, Abrams, JM, Alnemri, ES, Baehrecke, EH, Blagosklonny, MV. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 2012; 19: 107-120 [OpenAIRE] [PubMed]

Liu, Y, Shoji-Kawata, S, Sumpter, RM, Wei, Y, Ginet, V, Zhang, L. Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Proc Natl Acad Sci USA. 2013; 110: 20364-20371 [OpenAIRE] [PubMed]

Green, DR, Levine, B. To be or not to be? How selective autophagy and cell death govern cell fate. Cell. 2014; 157: 65-75 [OpenAIRE] [PubMed]

He, C, Bassik, MC, Moresi, V, Sun, K, Wei, Y, Zou, Z. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 2012; 481: 511-515 [OpenAIRE] [PubMed]

Choi, AM, Ryter, SW, Levine, B. Autophagy in human health and disease. N Engl J Med. 2013; 368: 651-662 [OpenAIRE] [PubMed]

Simonsen, A, Tooze, SA. Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J Cell Biol. 2009; 186: 773-782 [OpenAIRE] [PubMed]

Ohsumi, Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol. 2001; 2: 211-216 [OpenAIRE] [PubMed]

Kroemer, G, Levine, B. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol. 2008; 9: 1004-1010 [OpenAIRE] [PubMed]

Hofius, D, Schultz-Larsen, T, Joensen, J, Tsitsigiannis, DI, Petersen, NH, Mattsson, O. Autophagic components contribute to hypersensitive cell death in Arabidopsis. Cell. 2009; 137: 773-783 [OpenAIRE] [PubMed]

Hackenberg, T, Juul, T, Auzina, A, Gwizdz, S, Malolepszy, A, Van Der Kelen, K. Catalase and NO CATALASE ACTIVITY1 promote autophagy-dependent cell death in Arabidopsis. Plant Cell. 2013; 25: 4616-4626 [OpenAIRE] [PubMed]

Shimizu, S, Kanaseki, T, Mizushima, N, Mizuta, T, Arakawa-Kobayashi, S, Thompson, CB. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol. 2004; 6: 1221-1228 [OpenAIRE] [PubMed]

Shimizu, S, Konishi, A, Nishida, Y, Mizuta, T, Nishina, H, Yamamoto, A. Involvement of JNK in the regulation of autophagic cell death. Oncogene. 2010; 29: 2070-2082 [PubMed]

96 references, page 1 of 7
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publication . Article . Other literature type . 2014

Autosis and autophagic cell death: the dark side of autophagy

Liu, Y; Levine, B;