publication . Other literature type . Article . 2005

Linkage Disequilibrium Mapping of Quantitative-Trait Loci by Selective Genotyping

Chen, Zehua; Zheng, Gang; Ghosh, Kaushik; Li, Zhaohai;
Open Access English
  • Published: 01 Oct 2005
  • Publisher: The American Society of Human Genetics
Abstract
The principles of linkage disequilibrium mapping of dichotomous diseases can be well applied to the mapping of quantitative-trait loci through the method of selective genotyping. In 1999, M. Slatkin considered a truncation selection (TS) approach. We propose in this report an extended TS approach and an extreme-rank-selection (ERS) approach. The properties of these selection approaches are studied analytically. By using a simulation study, we demonstrate that both the extended TS approach and the ERS approach provide remarkable improvements over Slatkin’s original TS approach.
Subjects
free text keywords: Report, Genetics(clinical), Genetics, Gene mapping, Evolutionary biology, Genotyping, Linkage Disequilibrium Mapping, Biology, Linkage disequilibrium, Association mapping, Locus (genetics), Quantitative trait locus, Truncation selection
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue