publication . Other literature type . Article . 2005

Linkage Disequilibrium Mapping of Quantitative-Trait Loci by Selective Genotyping

Chen, Zehua; Zheng, Gang; Ghosh, Kaushik; Li, Zhaohai;
Open Access English
  • Published: 01 Oct 2005
  • Publisher: The American Society of Human Genetics
The principles of linkage disequilibrium mapping of dichotomous diseases can be well applied to the mapping of quantitative-trait loci through the method of selective genotyping. In 1999, M. Slatkin considered a truncation selection (TS) approach. We propose in this report an extended TS approach and an extreme-rank-selection (ERS) approach. The properties of these selection approaches are studied analytically. By using a simulation study, we demonstrate that both the extended TS approach and the ERS approach provide remarkable improvements over Slatkin’s original TS approach.
free text keywords: Report, Genetics(clinical), Genetics, Gene mapping, Evolutionary biology, Genotyping, Linkage Disequilibrium Mapping, Biology, Linkage disequilibrium, Association mapping, Locus (genetics), Quantitative trait locus, Truncation selection
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