publication . Other literature type . Article . Review . 2011

Hallmarks of Cancer: The Next Generation

Douglas Hanahan; Robert A. Weinberg;
  • Published: 01 Mar 2011
  • Country: Switzerland
Abstract
The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging h...
Subjects
free text keywords: Biochemistry, Genetics and Molecular Biology(all), Medicine, business.industry, business, Neuroscience, Immunoediting, Tumor microenvironment, Metastasis, medicine.disease, Cancer cell, Genetics, Cancer dormancy, The Hallmarks of Cancer, Immunology, Cancer systems biology, Cancer, Surgery, medicine.medical_specialty, General surgery
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Other literature type . Article . Review . 2011

Hallmarks of Cancer: The Next Generation

Douglas Hanahan; Robert A. Weinberg;