publication . Other literature type . Article . 2008

Structural insights into aberrant topological patterns of large-scale cortical networks in Alzheimer's disease.

He, Yong; Chen, Zhang; Evans, Alan;
Open Access
  • Published: 30 Apr 2008
  • Publisher: Society for Neuroscience
Abstract
Recent research on Alzheimer's disease (AD) has shown that cognitive and memory decline in this disease is accompanied by disrupted changes in the coordination of large-scale brain functional networks. However, alterations in coordinated patterns of structural brain networks in AD are still poorly understood. Here, we used cortical thickness measurement from magnetic resonance imaging to investigate large-scale structural brain networks in 92 AD patients and 97 normal controls. Brain networks were constructed by thresholding cortical thickness correlation matrices of 54 regions and analyzed using graph theoretical approaches. Compared with controls, AD patients ...
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