publication . Article . Other literature type . 2015

Predicting Reduction of Cerebrospinal Fluid β-Amyloid 42 in Cognitively Healthy Controls

Niklas Mattsson;
Open Access
  • Published: 01 May 2015 Journal: JAMA Neurology, volume 72, page 554 (issn: 2168-6149, Copyright policy)
  • Publisher: American Medical Association (AMA)
  • Country: Algeria
© 2015 American Medical Association. All rights reserved. IMPORTANCE Alzheimer disease has a long preclinical stage characterized by β-amyloid (Aβ) accumulation without symptoms. Several trials focus on this stage and use biomarkers to include Aβ-positive participants, but an even earlier prevention of Aβ accumulation may be an effective treatment strategy. OBJECTIVE To determine whether people who appear to be Aβ negative but are at high risk for Aβ positivity within the near future can be identified. DESIGN, SETTING, AND PARTICIPANTS Longitudinal biomarker cohort study involving 35 cognitively healthy individuals who underwent cerebrospinal fluid (CSF) samplin...
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