publication . Other literature type . Article . 2013

Posterior Cingulate Glucose Metabolism, Hippocampal Glucose Metabolism, and Hippocampal Volume in Cognitively Normal, Late-Middle-Aged Persons at 3 Levels of Genetic Risk for Alzheimer Disease

Hillary D. Protas; Kewei Chen; Jessica B. S. Langbaum; Adam S. Fleisher; Gene E. Alexander; Wendy Lee; Daniel Bandy; Mony J. de Leon; Lisa Mosconi; Shannon Buckley; ...
Open Access English
  • Published: 01 Mar 2013
Abstract
We and others have been using positron emission tomography (PET) measurements of the cerebral metabolic rate for glucose (CMRgl) in the posterior cingulate cortex and other brain regions that are known to be preferentially affected by Alzheimer disease (AD), magnetic resonance imaging (MRI) measurements of hippocampal and other brain tissue volumes, and other biomarker measurements to detect and track some of the brain changes that precede the clinical onset of AD.1–12 These findings have led our group and others to consider how these biomarkers could be used for people at increased risk for AD in the accelerated evaluation of presymptomatic AD treatments.8,12–1...
Subjects
free text keywords: Article, Precuneus, medicine.anatomical_structure, medicine, Anesthesia, Biomarker (medicine), Internal medicine, medicine.medical_specialty, Hippocampal formation, business.industry, business, Brain size, Neuroscience, Endocrinology, Hippocampus, Alzheimer's disease, medicine.disease, Posterior cingulate, Apolipoprotein E
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publication . Other literature type . Article . 2013

Posterior Cingulate Glucose Metabolism, Hippocampal Glucose Metabolism, and Hippocampal Volume in Cognitively Normal, Late-Middle-Aged Persons at 3 Levels of Genetic Risk for Alzheimer Disease

Hillary D. Protas; Kewei Chen; Jessica B. S. Langbaum; Adam S. Fleisher; Gene E. Alexander; Wendy Lee; Daniel Bandy; Mony J. de Leon; Lisa Mosconi; Shannon Buckley; ...