publication . Other literature type . Article . 1983

Influence of beta-adrenergic blockade on glucose-induced thermogenesis in man.

E. Jequier; K Acheson; J Wahren;
Open Access English
  • Published: 01 Sep 1983
Abstract
The role of beta-adrenergically mediated sympathetic nervous activity in the regulation of glucose-induced thermogenesis was examined in healthy male subjects. Respiratory gas exchange was measured continuously, using the ventilated hood technique, under conditions of hyperinsulinemia and hyperglycemia (glucose clamp technique, insulin infusion 1 mU/kg per min, glucose levels 125 mg/dl above basal) before and after beta-adrenergic blockade (i.v. propranolol, 3-mg bolus plus 0.1 mg/min for 2 h). After 2 h of insulin and glucose infusion in series 1, glucose uptake had increased to 23.5 +/- 2.3 mg/kg per min and insulin concentration to 199 +/- 21 microU/ml. Simul...
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free text keywords: Research Article, General Medicine, Endocrinology, medicine.medical_specialty, medicine, Glucose clamp technique, Propranolol, medicine.drug, Glucose uptake, Hyperinsulinism, medicine.disease, Thermogenesis, Insulin, medicine.medical_treatment, Hyperinsulinemia, Internal medicine, business.industry, business, Basal metabolic rate
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