publication . Article . Other literature type . 2016

A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

Shivani Aryal;
Open Access English
  • Published: 08 Dec 2016
  • Publisher: Elsevier
  • Country: Italy
Abstract
Abstract Introduction We hypothesized that common Alzheimer's disease (AD)-associated variants within the triggering receptor expressed on myeloid ( TREM ) gene cluster influence disease through gene expression. Methods Expression microarrays on temporal cortex and cerebellum from ∼400 neuropathologically diagnosed subjects and two independent RNAseq replication cohorts were used for expression quantitative trait locus analysis. Results A variant within a DNase hypersensitive site 5′ of TREM2 , rs9357347-C, associates with reduced AD risk and increased TREML1 and TREM2 levels (uncorrected P  = 6.3 × 10 −3 and 4.6 × 10 −2 , respectively). Meta-analysis on express...
Subjects
free text keywords: Alzheimer's disease, eQTL, TREM2, TREML1, Regulatory variant, Article, Health Policy, Developmental Neuroscience, Epidemiology, Cellular and Molecular Neuroscience, Geriatrics and Gerontology, Psychiatry and Mental health, Clinical Neurology, Expression quantitative trait loci, Biology, Locus (genetics), Temporal cortex, Genetics, Hypersensitive site, Microarray analysis techniques, Quantitative trait locus, Gene cluster
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