publication . Other literature type . Article . 2003

Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies

Paolo Radice; Nelson L S Tang; Heli Nevanlinna; Olli Kallioniemi; Gareth Evans; Håkan Olsson; siranoush manoukian;
Open Access
  • Published: 01 May 2003
  • Publisher: Elsevier BV
Abstract
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Estimates based on multiple-case families may be enriched for mutations of higher risk and/or other familial risk factors, whereas risk estimates from studies based on cases unselected for family history have been imprecise. We pooled pedigree data from 22 studies involving 8,139 index case patients unselected for family history with female (86%) or male (2%) breast cancer or epithelial ovarian cancer (12%), 500 of whom had been found to carry a germline mutation in BRCA1 or BRCA2. Breast and o...
Subjects
Medical Subject Headings: skin and connective tissue diseasesendocrine system diseases
free text keywords: Genetics(clinical), Genetics, Articles
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