publication . Article . Other literature type . 2006

a common genetic variant is associated with adult and childhood obesity

Herbert, A.;
Open Access
  • Published: 14 Apr 2006 Journal: Science, volume 312, pages 279-283 (issn: 0036-8075, eissn: 1095-9203, Copyright policy)
  • Publisher: American Association for the Advancement of Science (AAAS)
Abstract
Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.
Subjects
free text keywords: Multidisciplinary, Type 2 diabetes, medicine.disease, medicine, Genetic determinism, business.industry, business, Risk factor, Genotype, Genetics, Obesity, INSIG2, Framingham Heart Study, Childhood obesity
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http://dx.doi.org/10.1126/scie...
Other literature type . 2006
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Science
Article . 2006
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