publication . Article . Other literature type . 2013

Regulation of pyruvate metabolism and human disease

Lawrence R. Gray; Sean C. Tompkins; Eric B. Taylor;
Open Access English
  • Published: 21 Dec 2013 Journal: Cellular and Molecular Life Sciences, volume 71, issue 14, pages 2,577-2,604 (issn: 1420-682X, Copyright policy)
  • Publisher: Springer Nature
Abstract
Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in the cellular cytoplasm, and is ultimately destined for transport into mitochondria as a master fuel input undergirding citric acid cycle carbon flux. In mitochondria, pyruvate drives ATP production by oxidative phosphorylation and multiple biosynthetic pathways intersecting the citric acid cycle. Mitochondrial pyruvate metabolism is regulated by many enzymes, including the recently discovered mitochondria pyruvate carrier, pyruvate dehydrogenase, and pyruvate carboxylase, to modulate ov...
Subjects
free text keywords: Molecular Medicine, Cell Biology, Molecular Biology, Pharmacology, Cellular and Molecular Neuroscience, Review, Pyruvate, Mitochondria, Mitochondrial pyruvate carrier (MPC), Metabolism, Human disease, Pyruvate decarboxylation, Biology, Pyruvate dehydrogenase phosphatase, Biochemistry, Pyruvate dehydrogenase complex, Pyruvate dehydrogenase kinase, PKM2, Dihydrolipoyl transacetylase, Citric acid cycle, Pyruvate carboxylase
Related Organizations
Funded by
NIH| CARDIOVASCULAR INTERDISCIPLINARY RESEARCH FELLOWSHIP
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5T32HL007121-32
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| Vms1 is a Novel Protein Critical for Mitochondrial Maintenance
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R00AR059190-05
  • Funding stream: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
294 references, page 1 of 20

Bricker, DK, Taylor, EB, Schell, JC, Orsak, T, Boutron, A, Chen, YC, Cox, JE, Cardon, CM, Van Vranken, JG, Dephoure, N, Redin, C, Boudina, S, Gygi, SP, Brivet, M, Thummel, CS, Rutter, J. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science. 2012; 337 (6090): 96-100 [OpenAIRE] [PubMed]

Herzig, S, Raemy, E, Montessuit, S, Veuthey, JL, Zamboni, N, Westermann, B, Kunji, ER, Martinou, JC. Identification and functional expression of the mitochondrial pyruvate carrier. Science. 2012; 337 (6090): 93-96 [PubMed]

Tsutsumi, H, Tani, K, Fujii, H, Miwa, S. Expression of L- and M-type pyruvate kinase in human tissues. Genomics. 1988; 2 (1): 86-89 [OpenAIRE] [PubMed]

Takenaka, M, Noguchi, T, Sadahiro, S, Hirai, H, Yamada, K, Matsuda, T, Imai, E, Tanaka, T. Isolation and characterization of the human pyruvate kinase M gene. Eur J Biochem. 1991; 198 (1): 101-106 [PubMed]

Noguchi, T, Yamada, K, Inoue, H, Matsuda, T, Tanaka, T. The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters. J Biol Chem. 1987; 262 (29): 14366-14371 [PubMed]

Christofk, HR, Vander Heiden, MG, Harris, MH, Ramanathan, A, Gerszten, RE, Wei, R, Fleming, MD, Schreiber, SL, Cantley, LC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 2008; 452 (7184): 230-233 [OpenAIRE] [PubMed]

Yamada, K, Noguchi, T. Nutrient and hormonal regulation of pyruvate kinase gene expression. Biochem J. 1999; 337 (Pt 1): 1-11 [OpenAIRE] [PubMed]

Valentini, G, Chiarelli, LR, Fortin, R, Dolzan, M, Galizzi, A, Abraham, DJ, Wang, C, Bianchi, P, Zanella, A, Mattevi, A. Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia. J Biol Chem. 2002; 277 (26): 23807-23814 [OpenAIRE] [PubMed]

Larsen, TM, Laughlin, LT, Holden, HM, Rayment, I, Reed, GH. Structure of rabbit muscle pyruvate kinase complexed with Mn2+, K+, and pyruvate. Biochemistry. 1994; 33 (20): 6301-6309 [OpenAIRE] [PubMed]

Larsen, TM, Benning, MM, Rayment, I, Reed, GH. Structure of the bis(Mg2+)-ATP-oxalate complex of the rabbit muscle pyruvate kinase at 2.1 A resolution: ATP binding over a barrel. Biochemistry. 1998; 37 (18): 6247-6255 [PubMed]

Wang, C, Chiarelli, LR, Bianchi, P, Abraham, DJ, Galizzi, A, Mattevi, A, Zanella, A, Valentini, G. Human erythrocyte pyruvate kinase: characterization of the recombinant enzyme and a mutant form (R510Q) causing nonspherocytic hemolytic anemia. Blood. 2001; 98 (10): 3113-3120 [OpenAIRE] [PubMed]

Ashizawa, K, Willingham, MC, Liang, CM, Cheng, SY. In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate. J Biol Chem. 1991; 266 (25): 16842-16846 [PubMed]

Ikeda, Y, Noguchi, T. Allosteric regulation of pyruvate kinase M2 isozyme involves a cysteine residue in the intersubunit contact. J Biol Chem. 1998; 273 (20): 12227-12233 [PubMed]

Ikeda, Y, Tanaka, T, Noguchi, T. Conversion of non-allosteric pyruvate kinase isozyme into an allosteric enzyme by a single amino acid substitution. J Biol Chem. 1997; 272 (33): 20495-20501 [PubMed]

Zanella, A, Fermo, E, Bianchi, P, Chiarelli, LR, Valentini, G. Pyruvate kinase deficiency: the genotype-phenotype association. Blood Rev. 2007; 21 (4): 217-231 [OpenAIRE] [PubMed]

294 references, page 1 of 20
Abstract
Pyruvate is a keystone molecule critical for numerous aspects of eukaryotic and human metabolism. Pyruvate is the end-product of glycolysis, is derived from additional sources in the cellular cytoplasm, and is ultimately destined for transport into mitochondria as a master fuel input undergirding citric acid cycle carbon flux. In mitochondria, pyruvate drives ATP production by oxidative phosphorylation and multiple biosynthetic pathways intersecting the citric acid cycle. Mitochondrial pyruvate metabolism is regulated by many enzymes, including the recently discovered mitochondria pyruvate carrier, pyruvate dehydrogenase, and pyruvate carboxylase, to modulate ov...
Subjects
free text keywords: Molecular Medicine, Cell Biology, Molecular Biology, Pharmacology, Cellular and Molecular Neuroscience, Review, Pyruvate, Mitochondria, Mitochondrial pyruvate carrier (MPC), Metabolism, Human disease, Pyruvate decarboxylation, Biology, Pyruvate dehydrogenase phosphatase, Biochemistry, Pyruvate dehydrogenase complex, Pyruvate dehydrogenase kinase, PKM2, Dihydrolipoyl transacetylase, Citric acid cycle, Pyruvate carboxylase
Related Organizations
Funded by
NIH| CARDIOVASCULAR INTERDISCIPLINARY RESEARCH FELLOWSHIP
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5T32HL007121-32
  • Funding stream: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
,
NIH| Vms1 is a Novel Protein Critical for Mitochondrial Maintenance
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R00AR059190-05
  • Funding stream: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
294 references, page 1 of 20

Bricker, DK, Taylor, EB, Schell, JC, Orsak, T, Boutron, A, Chen, YC, Cox, JE, Cardon, CM, Van Vranken, JG, Dephoure, N, Redin, C, Boudina, S, Gygi, SP, Brivet, M, Thummel, CS, Rutter, J. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science. 2012; 337 (6090): 96-100 [OpenAIRE] [PubMed]

Herzig, S, Raemy, E, Montessuit, S, Veuthey, JL, Zamboni, N, Westermann, B, Kunji, ER, Martinou, JC. Identification and functional expression of the mitochondrial pyruvate carrier. Science. 2012; 337 (6090): 93-96 [PubMed]

Tsutsumi, H, Tani, K, Fujii, H, Miwa, S. Expression of L- and M-type pyruvate kinase in human tissues. Genomics. 1988; 2 (1): 86-89 [OpenAIRE] [PubMed]

Takenaka, M, Noguchi, T, Sadahiro, S, Hirai, H, Yamada, K, Matsuda, T, Imai, E, Tanaka, T. Isolation and characterization of the human pyruvate kinase M gene. Eur J Biochem. 1991; 198 (1): 101-106 [PubMed]

Noguchi, T, Yamada, K, Inoue, H, Matsuda, T, Tanaka, T. The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters. J Biol Chem. 1987; 262 (29): 14366-14371 [PubMed]

Christofk, HR, Vander Heiden, MG, Harris, MH, Ramanathan, A, Gerszten, RE, Wei, R, Fleming, MD, Schreiber, SL, Cantley, LC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 2008; 452 (7184): 230-233 [OpenAIRE] [PubMed]

Yamada, K, Noguchi, T. Nutrient and hormonal regulation of pyruvate kinase gene expression. Biochem J. 1999; 337 (Pt 1): 1-11 [OpenAIRE] [PubMed]

Valentini, G, Chiarelli, LR, Fortin, R, Dolzan, M, Galizzi, A, Abraham, DJ, Wang, C, Bianchi, P, Zanella, A, Mattevi, A. Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia. J Biol Chem. 2002; 277 (26): 23807-23814 [OpenAIRE] [PubMed]

Larsen, TM, Laughlin, LT, Holden, HM, Rayment, I, Reed, GH. Structure of rabbit muscle pyruvate kinase complexed with Mn2+, K+, and pyruvate. Biochemistry. 1994; 33 (20): 6301-6309 [OpenAIRE] [PubMed]

Larsen, TM, Benning, MM, Rayment, I, Reed, GH. Structure of the bis(Mg2+)-ATP-oxalate complex of the rabbit muscle pyruvate kinase at 2.1 A resolution: ATP binding over a barrel. Biochemistry. 1998; 37 (18): 6247-6255 [PubMed]

Wang, C, Chiarelli, LR, Bianchi, P, Abraham, DJ, Galizzi, A, Mattevi, A, Zanella, A, Valentini, G. Human erythrocyte pyruvate kinase: characterization of the recombinant enzyme and a mutant form (R510Q) causing nonspherocytic hemolytic anemia. Blood. 2001; 98 (10): 3113-3120 [OpenAIRE] [PubMed]

Ashizawa, K, Willingham, MC, Liang, CM, Cheng, SY. In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate. J Biol Chem. 1991; 266 (25): 16842-16846 [PubMed]

Ikeda, Y, Noguchi, T. Allosteric regulation of pyruvate kinase M2 isozyme involves a cysteine residue in the intersubunit contact. J Biol Chem. 1998; 273 (20): 12227-12233 [PubMed]

Ikeda, Y, Tanaka, T, Noguchi, T. Conversion of non-allosteric pyruvate kinase isozyme into an allosteric enzyme by a single amino acid substitution. J Biol Chem. 1997; 272 (33): 20495-20501 [PubMed]

Zanella, A, Fermo, E, Bianchi, P, Chiarelli, LR, Valentini, G. Pyruvate kinase deficiency: the genotype-phenotype association. Blood Rev. 2007; 21 (4): 217-231 [OpenAIRE] [PubMed]

294 references, page 1 of 20
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publication . Article . Other literature type . 2013

Regulation of pyruvate metabolism and human disease

Lawrence R. Gray; Sean C. Tompkins; Eric B. Taylor;