publication . Article . 2004

Effectiveness of leucoreduction for removal of infectivity of transmissible spongiform encephalopathies from blood

Luisa Gregori; Nancy McCombie; Douglas Palmer; Paul Birch; Samuel O Sowemimo-Coker; Antonio Giulivi; Robert G Rohwer;
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  • Published: 10 Aug 2004 Journal: The Lancet, volume 364, pages 529-531 (issn: 0140-6736, Copyright policy)
  • Publisher: Elsevier BV
Abstract
In 1999, the UK implemented universal leucoreduction as a precaution against transmission of variant Creutzfeldt-Jakob disease by transfusion of domestic blood or red blood cells. We aimed to assess how effectively leucoreduction reduced infectivity of transmissible spongiform encephalopathies (TSEs) in blood. 450 mL of whole blood collected and pooled from scrapie-infected hamsters was leucoreduced with a commercial filter. Blood cell concentrations were quantified, and infectivity titres measured. Blood cell recovery and white blood cell removal complied with American Association of Blood Banks standards. Leucofiltration removed 42% (SD 12) of the total TSE in...
Subjects
Medical Subject Headings: animal diseasesnervous system diseases
free text keywords: Blood transfusion, medicine.medical_treatment, medicine, Leukapheresis, Virology, White blood cell, medicine.anatomical_structure, Whole blood, Infectivity, Biological fluid, business.industry, business, Diabetes mellitus, medicine.disease, Blood cell, Intensive care medicine, medicine.medical_specialty
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