publication . Article . Other literature type . 2012

Aging and Down Syndrome

Head, Elizabeth; Silverman, Wayne; Patterson, David; Lott, Ira T.;
Open Access English
  • Published: 01 Jul 2012 Journal: Current Gerontology and Geriatrics Research, volume 2,012 (issn: 1687-7063, eissn: 1687-7071, Copyright policy)
  • Publisher: Hindawi Publishing Corporation
The initial clinical description of Down syndrome (DS) was made by Down in 1866 [1] and identified as trisomy of chromosome 21 by Lejeune et al. in 1959 [2]. DS, or trisomy 21, is one of the most common causes of intellectual disability (ID), and recent national prevalence estimates suggest that 14.47 per 10,000 live births are infants with DS, leading to an average of 6037 annual DS births [3]. This represents an increase from previous prevalence rates. Characteristic physical features, deficits in the immune and endocrine systems, and delayed cognitive development [4] can be present in children with DS. Improvements in medical care for children and adults with...
free text keywords: Editorial, Geriatrics, RC952-954.6, Article Subject, Geriatrics and Gerontology, Down syndrome, medicine.disease, medicine, Pediatrics, medicine.medical_specialty, Trisomy, OPHTHALMIC DISORDERS, Mortality rate, Quality of life, business.industry, business, Prevalence, Life expectancy, Intellectual disability
Funded by
NIH| Genetics Core
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P30HD024061-22
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publication . Article . Other literature type . 2012

Aging and Down Syndrome

Head, Elizabeth; Silverman, Wayne; Patterson, David; Lott, Ira T.;