publication . Article . 2017

Affimers proteins are versatile and renewable affinity reagents

Tiede, C; Bedford, R; Heseltine, SJ; Smith, G; Wijetunga, I; Ross, R; AlQallaf, D; Roberts, APE; Balls, A; Curd, A; ...
Open Access English
  • Published: 27 Jun 2017
  • Publisher: eLife Sciences Publications Ltd
  • Country: United Kingdom
Abstract
Molecular recognition reagents are key tools for understanding biological processes and are used universally by scientists to study protein expression, localisation and interactions. Antibodies remain the most widely used of such reagents and many show excellent performance, although some are poorly characterised or have stability or batch variability issues, supporting the use of alternative binding proteins as complementary reagents for many applications. Here we report on the use of Affimer proteins as research reagents. We selected 12 diverse molecular targets for Affimer selection to exemplify their use in common molecular and cellular applications includin...
Funded by
WT
Project
  • Funder: Wellcome Trust (WT)
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