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Publication . Article . 2016

Regulation of Autophagy By Signaling Through the Atg1/ULK1 Complex

Papinski, Daniel; Kraft, Claudine;
Open Access
English
Published: 01 May 2016 Journal: Journal of Molecular Biology, issue 9, pages 1,725-1,741 (issn: 00222836, Copyright policy )
Publisher: The Authors. Published by Elsevier Ltd.
Abstract
AbstractAutophagy is an intracellular degradation pathway highly conserved in eukaryotic species. It is characterized by selective or bulk trafficking of cytosolic structures—ranging from single proteins to cell organelles—to the vacuole or a lysosome, in which the autophagic cargo is degraded. Autophagy fulfils a large set of roles, including nutrient mobilization in starvation conditions, clearance of protein aggregates and host defence against intracellular pathogens. Not surprisingly, autophagy has been linked to several human diseases, among them neurodegenerative disorders and cancer. Autophagy is coordinated by the action of the Atg1/ULK1 kinase, which is the target of several important stress signaling cascades. In this review, we will discuss the available information on both upstream regulation and downstream effectors of Atg1/ULK1, with special focus on reported and proposed kinase substrates.
Subjects

Autophagy, Autophagy signaling, Atg1/ULK1 regulation, Atg1/ULK1 phosphorylation sites, Atg1/ULK1 substrates, Molecular Biology

Related Organizations
127 references, page 1 of 13

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Funded by
FWF| Architecture and function of the phagosome assembly site in autophagy
Project
  • Funder: Austrian Science Fund (FWF) (FWF)
  • Project Code: P 25522
  • Funding stream: Einzelprojekte
,
FWF| Mechanisms and hierarchy in autophagosome formation
Project
  • Funder: Austrian Science Fund (FWF) (FWF)
  • Project Code: P 28113
  • Funding stream: Einzelprojekte
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