publication . Article . Other literature type . 2013

Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial

Jean-Yves Reginster; J. Badurski; Nicholas Bellamy; William G. Bensen; Roland Chapurlat; Xavier Chevalier; Claus Christiansen; Harry K. Genant; Federico Navarro; Nasonov El; ...
Open Access
  • Published: 01 Feb 2013 Journal: Annals of the Rheumatic Diseases, volume 72, pages 179-186 (issn: 0003-4967, eissn: 1468-2060, Copyright policy)
  • Publisher: BMJ
Abstract
Objective. Background Strontium ranelate is currently used for osteoporosis. The international, double-blind, randomised, placebo-controlled Strontium ranelate Efficacy in Knee OsteoarthrItis triAl evaluated its effect on radiological progression of knee osteoarthritis. Methods. Patients with knee osteoarthritis (Kellgren and Lawrence grade 2 or 3, and joint space width (JSW) 2.5-5 mm) were randomly allocated to strontium ranelate 1 g/day (n=558), 2 g/day (n=566) or placebo (n=559). The primary endpoint was radiographical change in JSW (medial tibiofemoral compartment) over 3 years versus placebo. Secondary endpoints included radiological progression, Western On...
Subjects
Medical Subject Headings: musculoskeletal diseases
free text keywords: Immunology, General Biochemistry, Genetics and Molecular Biology, Immunology and Allergy, Rheumatology, Knee Osteoarthritis, Aged, Antirheumatic Agents/therapeutic use, Double-Blind Method, Female, Humans, Male, Middle Aged, Organometallic Compounds/therapeutic use, Osteoarthritis, Knee/drug therapy/radiography, Thiophenes/therapeutic use, Treatment Outcome, Human health sciences, General & internal medicine, Sciences de la santé humaine, Médecine générale & interne, Knee, Organometallic Compounds, Thiophenes, Antirheumatic Agents, Radiography, Clinical Sciences, Public Health and Health Services, Arthritis & Rheumatology, Clinical and Epidemiological Research, 1506, 1507, Outcomes research, Placebo-controlled study, Osteoarthritis, medicine.disease, medicine, Physical therapy, medicine.medical_specialty, Population, education.field_of_study, education, Osteoporosis, Strontium ranelate, medicine.drug, business.industry, business, Placebo, Knee pain, medicine.symptom, WOMAC, Internal medicine, Surgery, Clinical endpoint, lcsh:Diseases of the musculoskeletal system, lcsh:RC925-935
Related Organizations
40 references, page 1 of 3

1 Bijlsma JW Berenbaum F Lafeber FP Osteoarthritis: an update with relevance for clinical practice. Lancet 2011;377:2115–26 21684382 [OpenAIRE] [PubMed]

2 Cooper C Arden NK Excess mortality in osteoarthritis. BMJ 2011;342:d1407 21385808 [PubMed]

3 Zhang W Nuki G Moskowitz RW OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 2010;18:476–99 20170770 [PubMed]

4 Tat SK Pelletier JP Mineau F Strontium ranelate inhibits key factors affecting bone remodelling in human osteoarthritic subchondral bone osteoblasts. Bone 2011;49:559–67 21700005 [PubMed]

5 Henrotin Y Labasse A Zheng SX Strontium ranelate increases cartilage matrix formation. J Bone Miner Res 2001;16:299–308 11204430 [OpenAIRE] [PubMed]

6 Gulhan I Bilgili S Gunaydin R The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study. Arch Gynecol Obstet 2008;278:437–41 18322691 [OpenAIRE] [PubMed]

7 Bruyere O Delferriere D Roux C Effects of strontium ranelate on spinal osteoarthritis progression. Ann Rheum Dis 2008;67:335–9 17965119 [OpenAIRE] [PubMed]

8 Altman R Asch E Bloch D Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986;29:1039–49 3741515 [PubMed]

9 Kellgren MJ The epidemiology of chronic rheumatism: atlas of standard radiographs. 2nd edn Oxford, UK: Blackwell Scientific, 1963

10 Cooper C Reginster J-Y Chapurlat R Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of a randomised double-blind, placebo-controlled trial. Curr Med Res Opin 2012;28:231–9 22148897 [OpenAIRE] [PubMed]

11 Kothari M Guermazi A von Ingersleben G Fixed-flexion radiography of the knee provides reproducible joint space width measurements in osteoarthritis. Eur Radiol 2004;14:1568–73 15150666 [PubMed]

12 Gensburger D Roux JP Arlot M Influence of blinding sequence of radiographs on the reproducibility and sensitivity to change of joint space width measurement in knee osteoarthritis. Arthritis Care Res (Hoboken)2010;62:1699–705 20665746 [PubMed]

13 Botha-Scheepers S Watt I Breedveld FC Reading radiographs in pairs or in chronological order influences radiological progression in osteoarthritis. Rheumatology (Oxford)2005;44:1452–5 16091397 [PubMed]

14 Felson DT Nevitt MC Blinding images to sequence in osteoarthritis: evidence from other diseases. Osteoarthritis Cartilage 2009;17:281–3 18977156 [OpenAIRE] [PubMed]

15 Gensburger D Arlot M Sornay-Rendu E Radiologic assessment of age-related knee joint space changes in women: a 4-year longitudinal study. Arthritis Rheum 2009;61:336–43 19248124 [PubMed]

40 references, page 1 of 3
Abstract
Objective. Background Strontium ranelate is currently used for osteoporosis. The international, double-blind, randomised, placebo-controlled Strontium ranelate Efficacy in Knee OsteoarthrItis triAl evaluated its effect on radiological progression of knee osteoarthritis. Methods. Patients with knee osteoarthritis (Kellgren and Lawrence grade 2 or 3, and joint space width (JSW) 2.5-5 mm) were randomly allocated to strontium ranelate 1 g/day (n=558), 2 g/day (n=566) or placebo (n=559). The primary endpoint was radiographical change in JSW (medial tibiofemoral compartment) over 3 years versus placebo. Secondary endpoints included radiological progression, Western On...
Subjects
Medical Subject Headings: musculoskeletal diseases
free text keywords: Immunology, General Biochemistry, Genetics and Molecular Biology, Immunology and Allergy, Rheumatology, Knee Osteoarthritis, Aged, Antirheumatic Agents/therapeutic use, Double-Blind Method, Female, Humans, Male, Middle Aged, Organometallic Compounds/therapeutic use, Osteoarthritis, Knee/drug therapy/radiography, Thiophenes/therapeutic use, Treatment Outcome, Human health sciences, General & internal medicine, Sciences de la santé humaine, Médecine générale & interne, Knee, Organometallic Compounds, Thiophenes, Antirheumatic Agents, Radiography, Clinical Sciences, Public Health and Health Services, Arthritis & Rheumatology, Clinical and Epidemiological Research, 1506, 1507, Outcomes research, Placebo-controlled study, Osteoarthritis, medicine.disease, medicine, Physical therapy, medicine.medical_specialty, Population, education.field_of_study, education, Osteoporosis, Strontium ranelate, medicine.drug, business.industry, business, Placebo, Knee pain, medicine.symptom, WOMAC, Internal medicine, Surgery, Clinical endpoint, lcsh:Diseases of the musculoskeletal system, lcsh:RC925-935
Related Organizations
40 references, page 1 of 3

1 Bijlsma JW Berenbaum F Lafeber FP Osteoarthritis: an update with relevance for clinical practice. Lancet 2011;377:2115–26 21684382 [OpenAIRE] [PubMed]

2 Cooper C Arden NK Excess mortality in osteoarthritis. BMJ 2011;342:d1407 21385808 [PubMed]

3 Zhang W Nuki G Moskowitz RW OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage 2010;18:476–99 20170770 [PubMed]

4 Tat SK Pelletier JP Mineau F Strontium ranelate inhibits key factors affecting bone remodelling in human osteoarthritic subchondral bone osteoblasts. Bone 2011;49:559–67 21700005 [PubMed]

5 Henrotin Y Labasse A Zheng SX Strontium ranelate increases cartilage matrix formation. J Bone Miner Res 2001;16:299–308 11204430 [OpenAIRE] [PubMed]

6 Gulhan I Bilgili S Gunaydin R The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study. Arch Gynecol Obstet 2008;278:437–41 18322691 [OpenAIRE] [PubMed]

7 Bruyere O Delferriere D Roux C Effects of strontium ranelate on spinal osteoarthritis progression. Ann Rheum Dis 2008;67:335–9 17965119 [OpenAIRE] [PubMed]

8 Altman R Asch E Bloch D Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986;29:1039–49 3741515 [PubMed]

9 Kellgren MJ The epidemiology of chronic rheumatism: atlas of standard radiographs. 2nd edn Oxford, UK: Blackwell Scientific, 1963

10 Cooper C Reginster J-Y Chapurlat R Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of a randomised double-blind, placebo-controlled trial. Curr Med Res Opin 2012;28:231–9 22148897 [OpenAIRE] [PubMed]

11 Kothari M Guermazi A von Ingersleben G Fixed-flexion radiography of the knee provides reproducible joint space width measurements in osteoarthritis. Eur Radiol 2004;14:1568–73 15150666 [PubMed]

12 Gensburger D Roux JP Arlot M Influence of blinding sequence of radiographs on the reproducibility and sensitivity to change of joint space width measurement in knee osteoarthritis. Arthritis Care Res (Hoboken)2010;62:1699–705 20665746 [PubMed]

13 Botha-Scheepers S Watt I Breedveld FC Reading radiographs in pairs or in chronological order influences radiological progression in osteoarthritis. Rheumatology (Oxford)2005;44:1452–5 16091397 [PubMed]

14 Felson DT Nevitt MC Blinding images to sequence in osteoarthritis: evidence from other diseases. Osteoarthritis Cartilage 2009;17:281–3 18977156 [OpenAIRE] [PubMed]

15 Gensburger D Arlot M Sornay-Rendu E Radiologic assessment of age-related knee joint space changes in women: a 4-year longitudinal study. Arthritis Rheum 2009;61:336–43 19248124 [PubMed]

40 references, page 1 of 3
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