Regulation of differentiation by TGF-beta.
Copyright policy )Regulation of differentiation by TGF-beta.
Recent experiments in neural, skeletal, endothelial, and hematopoietic tissues have provided new insights into the way members of the transforming growth factor-beta (TGF-beta) superfamily regulate cellular differentiation. TGF-betas regulate the fate of multipotential stem cells instructively (in the neural crest) by regulating the expression or function of tissue-specific transcription factors, as well as selectively (in the mesenchyme) by regulating the expression of required growth factors and their receptors. During skeletal development, TGF-betas have unique functions and act sequentially to modulate chondrocyte and osteoblast differentiation. Responsiveness to TGF-betas changes as cells differentiate and evidence now suggests that changes in TGF-beta receptor profile may account for some of these differences. Drosophila and transgenic mouse models are now providing useful insights into mechanisms of TGF-beta action in vivo.
Mammals, Gene Expression Regulation, Developmental, Bone Marrow Cells, Cell Differentiation, Mice, Transgenic, Nervous System, Mice, Drosophila melanogaster, Bone Marrow, Transforming Growth Factor beta, Bone Morphogenetic Proteins, Animals, Blood Vessels, Humans, Inhibins, Nervous System Physiological Phenomena, Endothelium, Vascular, Muscle, Skeletal
Mammals, Gene Expression Regulation, Developmental, Bone Marrow Cells, Cell Differentiation, Mice, Transgenic, Nervous System, Mice, Drosophila melanogaster, Bone Marrow, Transforming Growth Factor beta, Bone Morphogenetic Proteins, Animals, Blood Vessels, Humans, Inhibins, Nervous System Physiological Phenomena, Endothelium, Vascular, Muscle, Skeletal
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