Despite several recently published optimistic reports on successful therapeutic regimens of postoperative endophthalmitis caused by coagulase-negative staphylococci this intraocular disease still represents a preeminent danger for ocular vision and the integrity of the globe. In this survey critical analyses of studies concerning infectious as well as the non-infectious intraocular inflammations have been reviewed. The demand for an initiation of "metastudies" seems appropriate in order to evaluate the many controversial data collections concerning the incidence, diagnosis and results of therapeutic interventions of postoperative endophthalmitis.