[Experimental study of the effectiveness of interleukin-1beta in radiation injury].

V I, Legeza; N G, Chigareva; N V, Petkevich; T P, Vasil'eva; Iu A, Abdul'; V N, Boĭko

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Russian journal of h...arrow_drop_down

Russian journal of hematology and transfusiology

Article . 1995

Data sources: Europe PubMed Central

[Experimental study of the effectiveness of interleukin-1beta in radiation injury].

descriptionPublicationkeyboard_double_arrow_right Article 21 Sep 1995 Russian Journal:Gematologiia i transfuziologiia, volume 40 (issn: 0234-5730,

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Authors: V I, Legeza; N G, Chigareva; N V, Petkevich; T P, Vasil'eva; Iu A, Abdul'; V N, Boĭko;

pmid: 7642073

[Experimental study of the effectiveness of interleukin-1beta in radiation injury].

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Abstract

The experiments on mice exposed to radiation (6.5 Gy, LD 80/30) discovered that human recombinant interleukin-1 beta after administration on postradiation hour 1-3 increased the animals' survival by 40-70%. Interleukin-1 beta reduced leukopenia and enhanced the recovery of bone marrow cell elements. The use of the preparation as an early pathogenetic treatment of irradiation damage holds promise.

Keywords

Male, Mice, Radiation Injuries, Experimental, Animals, Humans, Recombinant Proteins, Hematopoiesis, Interleukin-1

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