We explored and analyzed the effect and masticatory function of ultrasonic subgingival curettage combined with rinsing and gargling of Xipayi gingival rinse on patients with moderate to severe chronic periodontitis.We selected 98 patients with moderate to severe chronic periodontitis admitted to our hospital, and randomly divided them into observation group and control group (n=49 in each group). The control group was treated with ultrasonic subgingival curettage. The observation group received ultrasonic subgingival curettage with Xipayi gingival rinse, and continued to use-Xipayi gingival rinse for 4 weeks. The changes of periodontal index, inflammatory degree of gingival crevicular fluid, occlusal and masticatory efficiency before and after treatment were compared.The periodontal indexes and the degree of inflammatory factors in gingival crevicular fluid of the two groups post-treatment decreased critically than those of pre-treatment (P<0.05), and the periodontal index and the degree of inflammatory factors in gingival crevicular fluid of the observation group was remarkably lower than those of the control group (P<0.05). The occlusal time and the balance of occlusal force of the two groups decreased significantly post-treatment compared with those of pre-treatment (P<0.05), and the indexes in observation group were dramatically lower than those in control group (P<0.05). The standard deviation of masticatory efficiency in the two groups decreased remarkably post-treatment than that of pre-treatment (P<0.05), and the index in observation group was obviously lower than that in control group (P<0.05).The combined therapy of ultrasonic subgingival curettage and Xipayi gingival rinse can effectively cure moderate to severe chronic periodontitis. Through this treatment, patients can improve periodontal condition and inhibit periodontal inflammation. Meanwhile, patients can improve the stability of occlusion and increase the bite force, thus improving the chewing efficiency. Therefore, the application of this method is worthy of clinical application.