[The effect of alcohols on daily variations in aspartate amino- transferase activity in rat organs].

V I, Korkach; L D, Spitkovskaia; Iu G, Kul'chitskaia

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Article . 1990

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[The effect of alcohols on daily variations in aspartate amino- transferase activity in rat organs].

descriptionPublicationkeyboard_double_arrow_right Article 10 Jan 1990 Russian Journal:Ukrainskii biokhimicheskii zhurnal (1978), volume 61 (issn: 0201-8470,

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Authors: V I, Korkach; L D, Spitkovskaia; Iu G, Kul'chitskaia;

pmid: 2588342

[The effect of alcohols on daily variations in aspartate amino- transferase activity in rat organs].

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Abstract

The 7 day-long intragastric administration of ethanol and ethyleneglycol in a dose of 1/3 DL50 was studied for its effect on the circadian variations of the aspartate aminotransferase activity (AST, EC 2.6, 1.1) in the liver, brain, myocardium and kidney of male rats. The ethanol and ethylene glycol administration reduced the mean circadian enzymic activity in the above organs. Moreover, ethanol significantly reduced the amplitude of circadian variations of the AST activity in the liver, brain and kidney, while ethylene glycol--in the liver, myocardium and kidney.

Keywords

Male, Ethylene Glycol, Ethanol, Myocardium, Brain, Heart, Rats, Inbred Strains, Kidney, Circadian Rhythm, Rats, Liver, Animals, Ethylene Glycols, Aspartate Aminotransferases

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