[Purinergic P2-receptors as potential targets of new pharmaceutical products].
Copyright policy )[Purinergic P2-receptors as potential targets of new pharmaceutical products].
P2-receptors are widespread in animal and human organs and tissues. Therefore, they attract much attention as potential targets of new drugs. This article presents in brief characteristics of P2 receptors and reviews the author's search for new antagonists of P2-receptors as well as his studies on the role of ectonucleotidases and unique temperature-dependence of P2 receptor activity. In addition, the presence and functional activity of P2 receptors in human uterus, fallopian tubes, heart and blood vessels are described. The possible physiological and pathophysiological role of P2 receptors in these tissues, as well as prospects for the development of drugs acting via P2 receptors is discussed.
Male, Hot Temperature, Receptors, Purinergic P2, Uterus, Cardiovascular System, Cold Temperature, Adenosine Triphosphate, Drug Discovery, Purinergic P2 Receptor Antagonists, Humans, Female, Molecular Targeted Therapy, Fallopian Tubes, Signal Transduction
Male, Hot Temperature, Receptors, Purinergic P2, Uterus, Cardiovascular System, Cold Temperature, Adenosine Triphosphate, Drug Discovery, Purinergic P2 Receptor Antagonists, Humans, Female, Molecular Targeted Therapy, Fallopian Tubes, Signal Transduction
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