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Otizm Spektrum Bozukluğu Olan Olgularda Anne Sütü Alım Süreleri ve Otizm Şiddetiyle İlişkisi

Authors: Şahin, Nilfer; Balkan, Damla; Kırlı, Ulviye;

Otizm Spektrum Bozukluğu Olan Olgularda Anne Sütü Alım Süreleri ve Otizm Şiddetiyle İlişkisi

Abstract

Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorder characterized with social interaction, communication impairments and stereotypic behaviour. Although the aetiology of autism has not yet been fully elucidated, several hypotheses have been proposed to explain the aetiology of autism. Conditions related to breastfeeding, such as duration of breastfeeding, timing have been proposed as environmental risk factors for autism. The aim of this study was to evaluate the relationship between breastfeeding time and autism severity in children with ASD. The study included 88 children with autism who were diagnosed according to DSM-5 diagnostic criteria and 61 healthy age-matched children. Autism severity was assessed by the Childhood Autism Rating Scale (CARS). Demographic data and CARS scores were obtained by scanning the file information. Mean breastfeeding time was 12.97±8.13 months in the ASD group while breastfeeding time was 15.55±7.81 months in the control group. The difference between the groups was not statistically significant (p=0.055). There was a negative correlation between CARS scores and breast milk intake times in the ASD group (p<0.001, r: -0.435). In this study, breastfeeding times in children with ASD were similar to healthy controls. However, the severity of ASD was found to be increased as the duration of breastfeeding decreased in children with ASD. Further studies are needed to clarify the potential pathophysiological role of breastfeeding in the aetiology of ASD and its relationship with disease severity.

Otizm Spektrum Bozukluğu (OSB), sosyal etkileşim ve iletişimde bozulmalar ve stereotipik davranışlarla karakterize bir grup nörogelişimsel bozukluktur. Otizm etyolojisi henüz tam olarak aydınlatılamamış olmakla birlikte otizm etyolojisini açıklamak için birçok hipotez öne sürülmüştür. Anne sütü alım süreleri, zamanlamaları gibi emzirme ile ilgili durumlar, otizm için çevresel risk faktörleri olarak öne sürülmüştür. Bu çalışmada OSB’li çocuklarda anne sütü alım sürelerinin otizm şiddetiyle ilişkisinin değerlendirilmesi amaçlanmıştır. Çalışmaya DSM-5 tanı kriterlerine göre OSB tanısı almış 88 çocuk ve yaş ve cinsiyet olarak eşleştirilmiş 61 sağlıklı çocuğun verileri dahil edildi. Otizm şiddeti Çocukluk Otizm Dereceleme Ölçeği (ÇODÖ) ile değerlendirildi. OSB grubunda ortalama anne sütü alma süresi 12.97±8.13 ay iken kontrol grubunda bu süre 15.55±7.81 ay idi. Gruplar arasında ortaya çıkan bu fark istatistiksel olarak anlamlı değildi (p=0.055). OSB grubunda ÇODÖ puanlarıyla anne sütü alım süreleri arasında negatif korelasyon saptandı (p<0.001, r:-0.435). Bu çalışmada OSB’li çocuklarda anne sütü alım süreleri sağlıklı kontrollere benzer bulundu. Bununla birlikte OSB’li çocuklarda anne sütü alım süreleri kısaldıkça OSB şiddetinin arttığı bulundu. Anne sütünün OSB etiyolojisindeki potansiyel patofizyolojik rolünün ve hastalık şiddetiyle ilişkisinin aydınlatılması için daha geniş çaplı çalışmalara ihtiyaç vardır.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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