This paper has two complementary objectives: on the one hand, it introduces the EURO method for the estimation of (regional) Social Accounting Matrices. This method is widely used by Eurostat for the estimation of missing national Supply, Use and Input-output tables but it has not been used before within the context of social accounting matrices or of regional statistics and/or regional impact analyses. On the other hand, this work discusses the possibility of producing non-survey- based regional Social Accounting Matrices that may eventually allow the user to carry out impact analyses such as those of rural development policies, among others. The analysis is carried out for 12 selected European regions based on clusters.