The results of soil monitoring the Orenburg Region (from 2003 to 2007) were comparatively analyzed. The structure of soil pollution with gross (vanadium, lead, nickel, chromium, cobalt, manganese, copper, zinc, tin, titanium, boron, molybdenum) and mobile (cobalt, manganese, copper, zinc, chromium, nickel) compounds was revealed. The Orenburg Region's soils experience an anthropogenic load, as evidenced by a two-fold soil clarke excess as described by A. P. Vinogradov. The highest soil pollution has been established in the eastern region that is most industrially developed. The presumable associations with possible pollution sources are outlined. Correlation analysis has revealed the inter-environmental distribution of trace elements in foodstuffs and the population's biological media.