This chapter evaluated the effectiveness of existing selected findings regarding the removal of endocrine disruptors. Majority of them are based on laboratory experiments, only some of them was tested for scale-up applications, which is inevitable for practical use. The chapter provides an overview of the most commonly used types of processes for the removal of significant pollutants, including endocrine disruptors. So-called advanced oxidation processes seem to be the most promising technique. They can be combined with separation methods (by membranes) or adsorption, necessary for final water purification. Regarding our experience supported by the critical analysis of previous knowledge, advanced oxidation processes in a sequence with adsorption of final traces of nano-pollutants seems to be the safest technology for decontamination of all types of water, including effluents from municipal water treatment plants. \nThe closing part of the chapter presents the results from a pilot experiment of decontamination of real effluents from one selected municipal wastewater treatment plant where contaminated water is treated photocatalytically at a continuous flow of over 300 L/h. The achieved efficiency of water decontamination seems to be promising, especially concerning the possibility of recycling effluents, including those from wastewater treatment plants. \n\n