With the rapid expansion of the airline industry in all sectors, dentists should pay special attention to crews and frequent flyers, due to change of pressure in-flight, that cause different types of oro-facial pain. Aviation dentistry deals with evaluation, principles of prevention, treatment of diseases, disorders or conditions which are related to oral cavity and maxillofacial area or adjacent and associated structures and their impact on people who travel or on aircrew members and flight restrictions. Dentists should prevent the creation of in-flight hazards when they treat aircrew members and frequent flyers.