Devido ao crescente uso de canabidiol (CBD), é provável que ocorra interações quando administrado junto a medicamentos. Produtos de cannabis medicinal contêm uma variedade de fitocanabinoides, incluindo 9-tetrahidrocanabinol (9-THC), que é psicoativo, e o CBD sem efeitos eufóricos. Interações farmacodinâmicas podem ocorrer se a cannabis medicinal for administrada junto a medicamentos depressores do sistema nervoso central. Objetivo: fornecer orientação clínica sobre possíveis interações medicamentosas entre o CBD e outros medicamentos prescritos simultaneamente. Método: Esse estudo é uma revisão narrativa que busca sintetizar e discutir a farmacocinética e as principais enzimas, transportadores e receptores celulares, responsáveis pelos mecanismos das interações medicamentosas do CBD. 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