The objective of steganography is to conceal the presence of a secret communication. Nevertheless, with the development of steganalytic attack, also known as steganalysis, there are many statistical methods to estimate the presence and ratio of secret messages. The chi square (χ2) attack and regular-singular (RS) attack are two well recognized and widely applied statistical steganalysis schemes. In this paper, a new image steganography scheme with location selection is proposed to resist statistical steganalysis. The experiment results indicate that the proposed method can resist both χ2 attacks as well as RS attacks.