Drugs or medicinal organic molecules can change by hydrolyzed or elimination based on the reaction circumstances. In addition, they may disintegrate by polymerization, oxidizing, or isomerization. The purpose of this chapter is to highlight the chemical reactions behind medication stability. Techniques might be helpful in this situation to describe how compounds develop in a chemical change media. Drugs degrade in accordance with the atmosphere in which they are being reacted to. In order to find solutions to maintain therapeutic efficacy, it is important to comprehend the circumstances that affect drug security. In fact, chemical or physical breakdown can affect a drug's therapeutic efficiency and produce unwanted byproducts.