HIV and AIDS continues to ravage developing countries especially those in sub-Saharan Africa three decades into the pandemic. It has eroded social, political and economic health gains and dealing with its consequences is one of the greatest challenges of the new the millennium. There has been a decline in life expectancy in adults, an increase in child mortality rates that has reversed the years of hard won gains achieved in child survival, deepening poverty and exacerbation of food shortages. Susceptibility to HIV AIDS is sustained by the lack of economic, social and political influence, including the capability to effectively inform decision makers and policymakers. The majority of people affected by HIV/AIDS are vulnerable populations who live under conditions of gender-based violence, poor access to health care and inadequate living conditions. There is an urgent need for strategies to remove the barriers that prevent them from voluntary testing and counselling and accessing oral health promotion, prevention and treatment services.