A municipality is an administrative division composed of a defined territory and population (Al-Salem and Lettieri, 2009). While there are many varieties of municipalities, most fall into one of two categories: a single settlement and a land area similar to a township that may contain multiple settlements, or even just part of one, such as a city's municipality. Municipal Solid Waste (MSW) can be defined as solid waste which includes all domestic refuse and non-hazardous wastes such as commercial and institutional wastes, street sweepings and construction debris (Magutu et al., 2010). The major types of MSW are food wastes, paper, plastic, rags, metal and glass, with some hazardous household wastes such as electric light bulbs, batteries, discarded medicines and automotive parts. MSW is thus seen as primarily coming from households but also includes wastes from offices, hotels, shopping complexes/shops, schools, institutions, and from municipal services such as street cleaning and maintenance of recreational areas. In some countries the solid wastes management system also handles human wastes such as night-soil, ashes from incinerators, septic tank sludge and sludge from sewage treatment plants. The complexities and enormity of the challenges become evident when considering other waste types to be managed and these include industrial solid waste, municipal wastewater, industrial wastewater, storm water and hazardous waste. This chapter will focus on the major ways of managing the Municipal Solid Waste, especially through the proper long-term strategies by looking at the following four key areas: Formulation of the municipal solid waste management strategy; Objectives of municipal solid waste management; Waste management strategies used in municipal solid waste management; and lastly the challenges facing the implementation of sound municipal solid waste management strategies