<p><strong>Background. </strong><em>Annona muricata</em> has been reported as a potential nutraceutical based mainly on <em>in vitro</em> studies. <strong>Objective. t</strong>o determine potential toxicity and nutritional value of <em>Annona muricata</em> leaf flour using <em>in vitro</em> gas production (IVGP), dry and organic matter digestibility (IVDMD, IVOMD) as well as <em>in vivo</em> voluntary intake and apparent digestibility on Criollo kids. <strong>Methodology.</strong> <em>In vitro</em> trials were carried out with and without the tannin blocking agent polyethylene glycol (PEG). Kids (n=22) were fed with 0% (control, n=5), 2.5% (T2, n=6), 5% (T3, n=6) and 10% (T4, n=5) of <em>A. muricata</em> flour, intake and hepatic function were monitored. <strong>Results.</strong> The IVGP was lower (<em>P</em>&lt;0.05) with increasing <em>A. muricata</em> inclusion, but without difference on the IVDMD or IVOMD (<em>P</em>&gt;0.05). PEG inclusion had no effect (<em>P</em>&gt;0.05). The T4 caused 100% feed refusal. Intake was 396a, 379a and 203b g DM (S.E.D. 0.038) for control, T2 and T3 respectively (<em>P</em>&lt;0.05). The IVGP of <em>A. muricata</em> was low but not associated to the presence of condensed tannins. <strong>Implications.</strong> Due to reduced feed intake further studies are needed to identify the compound responsible of such effects. <strong>Conclusion.</strong> Although based on chemical composition and IVDMD and IVOMD <em>A. muricata</em> leaves can be qualified as medium quality fed, its use can only be recommended up to 2.5% diet inclusion, above such level toxicity might arise in growing goats.</p>