The development of information systems in health care is approaching the process of integration of various systems used in a single computer so that we witness today the omnipresent idea of merging the functions of the clinical-hospital (CHIS) and radiology (RIS) information system. Radiological Information System (RIS) is a technology solution to complete computerization and modernization of the work of the radiology center, and transition from film to paper and full electronic management and digital recordings. RIS creates the digital radiology center where information is always available at the right place and at the right time. Within the realization of RIS, it is necessary to follow the standards and systems relating to the specific RIS, which are: DICOM (Digital Imaging and Communications in Medicine), PACS (Picture Archiving and Communication System), HL7 (Health Level Seven). The relevant links of modern RIS are teleradiology and mobile radiology. The authors conclude that the introduction of RIS, HIS and other information systems are reflected in the automation, reduction of possible errors, increase in diagnostic and therapeutic quality, lower costs for materials, the increase in efficiency, saving time and others.