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Publication . Article . 2012

Synthesis and in vitro Biological Activity of New 4,6-Disubstituted 3(2H)-Pyridazinone-acetohydrazide Derivatives

Murat Sukuroglu; Tijen Önkol; Fatma Kaynak Onurdağ; Gulsen Akalın; M. Fethi Şahin;
Open Access
English
Published: 01 Jan 2012
Publisher: Verlag Z Naturforsch
Country: Turkey
Abstract
New 3(2H)-pyridazinone derivatives containing a N'-benzyliden-acetohydrazide moiety at position 2 were synthesized. The structures of these newly synthesized compounds were confirmed by IR, H-1 NMR, and MS data. These compounds were tested for their antibacterial, antifungal, antimycobacterial, and cytotoxic activities. The compounds 2-[4-(4-chlorophenyl)-6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-2-yl]-N'-(4-tert-butylbenzyliden)acetohydrazide and 2-[4-(4-chlorophenyl)-6-(morpholin-4-yl)-3-oxo-(2H)-pyridazin-2-yl]-N'-(4-chlorobenzyliden) acetohydrazide exhibited activity against both Gram-positive and Gram-negative bacteria. Most of the compounds were active against E. coli ATCC 35218. The preliminary results of this study revealed that some target compounds exhibited promising antimicrobial activities.
This study was supported by Gazi University Research Fund (project no. 02/2009-05).
Gazi University Research Fund [02/2009-05]
WOS: 000308054900004
PubMed ID: 22888530
Subjects by Vocabulary

Microsoft Academic Graph classification: Biological activity Moiety Antimycobacterial medicine.drug_class medicine Gram-positive bacteria biology.organism_classification biology Antimicrobial Stereochemistry In vitro Proton NMR Chemistry Nuclear magnetic resonance spectroscopy

Subjects

Antimicrobial Activity, Benzyliden-Acetohydrazide, Pyridazinone, General Biochemistry, Genetics and Molecular Biology

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