A liposome has been applied to cosmetics field as a bio-membrane model and a vehicle of various products, especially skin care cosmetics. In this review, I introduce some experimental results related to an application of liposome technique to cosmetics.In order to evaluate a safety of low materials and final products of cosmetics, liposomes are used as bio-membrane model instead of using some animals. The interaction between liposomes and some surfactants was studied and the results gave a good correlation with the known safety data. Moreover, liposomes comprised of stratum corneum lipids were examined as skin membrane models.On the other hand, there are many reports concerning percutaneous penetration using liposomes as a drug-carrier. These report indicate that liposomes have an ability for improvement of an accumulation of drugs (or humectants) to the skin. That is, besides being a humectant, a liposome is a desirable drug-carrier for cosmetics.