publication . Article . 2017

Antibacterial Activities of New Saturated Heterocyclic Nitrogen Compounds

Lefrada, Leila; Köhn, Randolf D.; Souhila Malki; Mazouz, Wissam; Ahcene Bouchemma; Meriem Hadjem;
Open Access
  • Published: 11 Sep 2017
  • Publisher: Zenodo
This work describes the synthesis, spectroscopic, structural characterization and antibacterial activities of new saturated heterocyclic nitrogen compounds of the 1, 3, 5-triazacyclohexane type. The new triazacyclohexanes (R3TAC) with mixed aryl and alkyl N-substituents are synthesized by the reaction of a 1:1 mixture of 4-iodoaniline and 2-ethyl1-hexyl amine with formalin. The synthesized compounds were characterized by spectral analysis IR, 1H NMR and 13C NMR and shown to be mainly a mixture of the two mixed triazacylcohexane. These compounds were screened for their antibacterial activity against Gram-positive and Gram-negative bacteria by the diffusion method on agar medium.      
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free text keywords: synthesis, triazacyclohexanes, antibacterial activity
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Open Access
Article . 2017
Providers: ZENODO
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