This clinical case describes the successful treatment of psoriasis vulgaris in a patient through a multifaceted approach including dietary modifications, vitamin D supplementation, and probiotics. Initial laboratory findings revealed an ANA (+) result, lipid abnormalities, and a deficiency in cholecalciferol and calcitriol. The patient was prescribed 60,000 IU of cholecalciferol with necessary cofactors, leading to partial improvement in symptoms after five months. The dose was increased to 100,000 IU D3, and probiotics were added to the regimen. After nine months of treatment, complete remission of psoriasis was observed, with laboratory findings showing significant improvements in calcifediol and calcitriol levels, normal Ca+ levels, and lower PTH. These results demonstrate the potential benefits of a comprehensive approach to managing psoriasis, addressing underlying nutritional deficiencies, dysbiosis and lifestyle factors.