Powered by OpenAIRE graph
Found an issue? Give us feedback
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ ZENODOarrow_drop_down
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ZENODO
Article . 2023
License: CC BY
Data sources: Datacite
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ZENODO
Article . 2023
License: CC BY
Data sources: ZENODO
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ZENODO
Article . 2023
License: CC BY
Data sources: Datacite
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
ZENODO
Article . 2023
License: CC BY
Data sources: ZENODO
versions View all 4 versions
addClaim

This Research product is the result of merged Research products in OpenAIRE.

You have already added 0 works in your ORCID record related to the merged Research product.

A REVIEW ON TREATMENT OF PRIMARY IMMUNE THROMBOCYTOPENIA

Authors: J.S. Venkatesh, Mr.Vinuth Chikkamath, Mahin M G*, Neethu Samuel*, Nimmy Babu*and Nimmy P George*;

A REVIEW ON TREATMENT OF PRIMARY IMMUNE THROMBOCYTOPENIA

Abstract

An autoimmune disease called immune thrombocytopenic purpura (ITP) affects roughly 1 in 10,000 people worldwide. A platelet count of less than 100 x 109L has historically been used to describe it, however symptoms are more often used to guide treatment than the actual platelet count. Corticosteroids have traditionally been the first line of treatment for patients with primary idiopathic ITP, with intravenous immune globulin (IVIG) or Rho(D) immune globulin (anti-RhD) being added for steroid-resistant instances. Second-line treatment options for ITP include splenectomy or rituximab, a monoclonal antibody that targets the CD20 antigen (anti-CD20).. The diagnosis of "chronic refractory ITP" is warranted in patients who continue to experience severe thrombocytopenia and symptomatic bleeding despite first- and second-line therapies, and third-line therapies are considered.

49 references, page 1 of 5

1. Kistangari G, McCrae KR: Immune thrombocytopenia. Hematol Oncol Clin North Am. 2013, 27:495-520. 10.1016/j.hoc.2013.03.001 [OpenAIRE]

2. Zufferey A, Kapur R, Semple JW: Pathogenesis and therapeutic mechanisms in immune thrombocytopenia (ITP). J Clin Med. 2017, 6:16. 10.3390/jcm6020016

3. Cines DB, Bussel JB, Liebman HA, Luning Prak ET: The ITP syndrome: pathogenic and clinical diversity . Blood. 2009, 113:6511-6521. 10.1182/blood-2009-01-129155 [OpenAIRE]

4. Cines DB, Blanchette VS: Immune thrombocytopenic purpura. N Engl J Med. 2002, 346:995-1008. 10.1056/NEJMra010501 [OpenAIRE]

5. Lambert MP, Gernsheimer TB: Clinical updates in adult immune thrombocytopenia . Blood. 2017, 129:2829- 2835. 10.1182/blood-2017-03-754119 [OpenAIRE]

6. Neunert C, Lim W, Crowther M, Cohen A, Solberg L, Jr., Crowther MA: The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood. 2011, 117:4190-4207. 10.1182/blood-2010-08- 302984 [OpenAIRE]

7. Cheng Y, Wong RS, Soo YO, et al.: Initial treatment of immune thrombocytopenic purpura with highdose dexamethasone. N Engl J Med. 2003, 349:831-836. 10.1056/NEJMoa030254

8. Mazzucconi MG, Fazi P, Bernasconi S, et al.: Therapy with high-dose dexamethasone (HDDXM) in previously untreated patients affected by idiopathic thrombocytopenic purpura: A GIMEMA experience. Blood. 2007, 109:1401- 1407. 10.1182/blood-2005-12-015222

9. Sakamoto K, Nakasone H, Tsurumi S, et al.: Prednisone versus high-dose dexamethasone for untreated primary immune thrombocytopenia. A retrospective study of the Japan Hematology & Oncology Clinical Study Group. J Thromb Thrombolysis. 2014, 37:279-286. 10.1007/s11239-013-0939-3

10. Matschke J, Muller-Beissenhirtz H, Novotny J, et al.: A randomized trial of daily prednisone versus pulsed dexamethasone in treatment-naive adult patients with immune thrombocytopenia: EIS 2002 study. Acta Haematol. 2016, 136:101-107. 10.1159/000445420

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
    OpenAIRE UsageCounts
    Usage byUsageCounts
    visibility views 26
    download downloads 24
  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
    Powered byBIP!BIP!
  • 26
    views
    24
    downloads
    Powered byOpenAIRE UsageCounts
Powered by OpenAIRE graph
Found an issue? Give us feedback
visibility
download
citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
views
OpenAIRE UsageCountsViews provided by UsageCounts
downloads
OpenAIRE UsageCountsDownloads provided by UsageCounts
0
Average
Average
Average
26
24
Green