ABSTRACT The present work focused on preparing hydroalcoholic extracts of Mangifera indica and Ocimum sanctum leaves and establishing the anti-inflammatory potential of the combined extracts in experimental model. The extraction yield of the hydroalcoholic mixture was found to be 36.2 % for Mangifera indica and 43.7 % for Ocimum sanctum. The findings of preliminary phytochemical analysis suggest the presence of alkaloids, saponin glycosides, phenolics, terpenoids, and flavonoids in the leaf of the Mangifera indica while alkaloids, sterols and glycosides were not present in Ocimum sanctum. The total phenolic content of the extracts of M. indica and O. sanctum were 26.86 ± 0.308 and 37.56 ± 0.665 GAE mg/g, respectively. The phenolic content was highest in the combined extract (CE, 1:2) of all the three combinations with total phenolics 81.53 ± 1.855 GAE mg/g. The extracts were individually and in combination (1:1, 1:2 & 2:1) subjected to determination of anti-inflammatory potential using carrageenan induced rat paw edema model. Ibuprofen at dose of 10 mg/Kg inhibited 69.23% edema after 4h of administration whereas the maximum edema inhibition exhibited by the combined extracts was 52.47% (MIE:OSE, 1:2) at the end of 4h. The anti-inflammatory action was consistent with the phenolic content of the extracts; with a higher amount of OSE in the mixture presenting a better inhibition of paw-edema. Keywords: Mangifera indica, Ocimum sanctum, paw edema, anti-inflammatory, phenolics